Chronic Inflammatory Pain Impairs mGluR5-Mediated Depolarization-Induced Suppression of Excitation in the Anterior Cingulate Cortex

Cerebral Cortex
Baolin GuoShengxi Wu

Abstract

The anterior cingulate cortex (ACC) is a critical hub for nociceptive perception and pain-related anxiety. Long-term synaptic plasticity in ACC was found to be important for chronic inflammatory pain and pain-related anxiety. As short-term synaptic plasticity, depolarization-induced suppression of excitation (DSE) is involved in several conditions, such as chronic stress, epilepsy, and autism. However, it is still unknown whether DSE in the ACC is involved in the central sensitization of pain and anxiety. Using a whole-cell patch clamp, calcium imaging, western blot, and behavioral testing, we found that DSE was induced by a 2 s depolarization in postsynaptic pyramidal cells in ACC. DSE was mediated by endocannabinoid signaling and modulated by metabotropic glutamate receptor 5 (mGluR5). DSE was impaired by decreasing expression and dysfunction of mGluR5 in a mouse model of inflammatory pain induced by complete Freund's adjuvant. CDPPB, an mGluR5-positive allosteric modulator, could rescue hypersensitivity and anxiety-like behavior in this pain model. Our results demonstrated that mGluR5-mediated short-term plasticity in ACC may be a critical mechanism for chronic pain, and mGluR5 may potentially serve as a target of pain thera...Continue Reading

References

May 8, 1995·The Journal of Comparative Neurology·C RomanoJ W Olney
Apr 10, 2003·British Journal of Pharmacology·Jesper Mosolff MathiesenM Teresa Ramirez
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Long-Jun WuMin Zhuo
Feb 10, 2006·Journal of Neurophysiology·Masako Isokawa, Bradley E Alger
Apr 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Motokazu UchigashimaMasahiko Watanabe
Mar 11, 2008·Trends in Neurosciences·Min Zhuo
Mar 30, 2010·Cerebral Cortex·Zizhen Zhang, Philippe Séguéla
Oct 16, 2010·Nature Medicine·Rohini Kuner
Oct 29, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kornelia KamprathHans-Christian Pape
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Enza PalazzoSabatino Maione
Apr 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vanessa A MitchellChristopher W Vaughan
Jan 17, 2012·Behavioural Brain Research·Alexandre J ParentLouis Gendron
Apr 24, 2012·Neuropharmacology·Takaki KiritoshiVolker Neugebauer
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lara W CrockRobert W Gereau
Oct 23, 2012·Neuron·Qian ChenGuoping Feng
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sabine RuehleBeat Lutz
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mei HanYu-Qiu Zhang
May 17, 2014·Trends in Neurosciences·Ceng LuoRohini Kuner
Aug 16, 2014·Journal of Computational Neuroscience·Margarita Zachariou, Rüdiger Thul
Aug 26, 2014·Neurochemical Research·Marion S Mercier, David Lodge

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Citations

May 18, 2020·International Journal of Molecular Sciences·Kai K KummerMichaela Kress
May 20, 2020·Frontiers in Psychiatry·Guohong CaiShengxi Wu
Dec 29, 2020·CNS Neuroscience & Therapeutics·Feifei ZhangQiyong Gong
Oct 21, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Faith BorganOliver Howes

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