Chronic ingestion of a Western diet increases O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the rat heart.

Life Sciences
Heidi M MedfordSusan A Marsh

Abstract

Protein O-GlcNAcylation is both a nutrient sensing and cellular stress response that mediates signal transduction in the heart. Chronically elevated O-GlcNAc has been associated with the development of cardiac dysfunction at both the cellular and organ levels in obesity, insulin resistance and diabetes. Development of these pathologies is often attributed to diets high in saturated fat and sugar (a "Western" diet; WES) but a role for O-GlcNAc in diet-induced cardiac dysfunction has not been established. The aims of this study were to examine the effect of chronic consumption of WES on cardiac O-GlcNAcylation and investigate associations of O-GlcNAc with cardiac function and markers of cellular stress. Young male rats received either a control diet (CON; n=9) or WES (n=8) diet for 52 weeks. There was no evidence of cardiac dysfunction, advanced glycation endproduct (AGE) accumulation, pathological cardiac hypertrophy, calcium handling impairment, fibrosis or endoplasmic reticulum stress in WES hearts. However, cardiac O-GlcNAc protein, particularly in the higher molecular weight range, was significantly higher in WES hearts compared to CON (P<0.05). Protein levels of the enzymes that regulate O-GlcNAc attachment were not differe...Continue Reading

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Citations

May 7, 2013·Annual Review of Nutrition·Michelle R Bond, John A Hanover
Sep 10, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jason P MyslickiJane Shearer
Nov 13, 2012·Life Sciences·J D GardnerL E Wold
Mar 5, 2015·Antioxidants & Redox Signaling·Anne D HafstadEllen Aasum
Mar 2, 2017·The Journal of Biological Chemistry·Stephanie Olivier-Van StichelenJohn A Hanover
Aug 30, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Yabing ChenHui Wu
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Aug 22, 2020·Journal of Lipid and Atherosclerosis·Chang Hyun Byon, Soo Wan Kim
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heidi M MedfordSusan A Marsh
Nov 14, 2018·Frontiers in Endocrinology·Simon DucheixXavier Prieur
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Oct 5, 2021·Circulation Research·Sarah E BasehoreAlisa Morss Clyne

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