Chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. Workshop report

Regulatory Toxicology and Pharmacology : RTP
V VuD Y Lai

Abstract

On May 8-10, 1995, a workshop on chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles was held in Chapel Hill, North Carolina. The workshop was sponsored by the Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency (EPA), in collaboration with the National Institute of Environmental Health Sciences (NIEHS), the National Institute for Occupational Safety and Health (NIOSH), and the Occupational Safety and Health Administration (OSHA). The goal of the workshop was to obtain input from the scientific community on a number of issues related to fiber testing. Major issues for discussion were: (i) the optimal design and conduct of studies of the health effects of chronic inhalation exposure of animals to fibers; (ii) preliminary studies which would be useful guides in designing the chronic exposure study; (iii) mechanistic studies which would be important adjuncts to the chronic exposure study to enable better interpretation of study results and extrapolation of potential effects in exposed humans; and (iv) available screening tests which can be used to develop a minimum data set for (a) making decisions about the potential health hazard of the fibers and (b) prioritizing t...Continue Reading

Citations

Jul 26, 2005·Inhalation Toxicology·David BernsteinUNKNOWN ILSI Risk Science Institute Working Group
Sep 13, 2015·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Günter OberdörsterPhil Sayre
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brooke T MossmanJames C Bonner

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