Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection.

Vaccine
Matthew P BernardRichard P Phipps

Abstract

Generation of optimal humoral immunity to vaccination is essential to protect against devastating infectious agents such as the variola virus that causes smallpox. Vaccinia virus (VV), employed as a vaccine against smallpox, provides an important model of infection. Herein, we evaluated the importance cyclooxygenase-2 (Cox-2) in immunity to VV using Cox-2 deficient mice and Cox-2 selective inhibitory drugs. The effects of Cox-2 inhibition on antibody responses to live viruses such as vaccinia have not been previously described. Here, we used VV infection in Cox-2 deficient mice and in mice chronically treated with Cox-2 selective inhibitors and show that the frequency of VV-specific B cells was reduced, as well as the production of neutralizing IgG. VV titers were approximately 70 times higher in mice treated with a Cox-2 selective inhibitor. Interestingly, Cox-2 inhibition also reduced the frequency of IFN-gamma producing CD4(+) T helper cells, important for class switching. The significance of these results is that the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), and other drugs that inhibit Cox-2 activity or expression, blunt the ability of B cells to produce anti-viral antibodies, thereby making vaccines l...Continue Reading

References

Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
Nov 5, 2002·Immunology Letters·Rachel L RoperRichard P Phipps
Jul 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Igor M BelyakovJay A Berzofsky
Aug 20, 2003·Nature Medicine·Erika HammarlundMark K Slifka
Apr 17, 2004·Journal of Immunological Methods·Shane CrottyRafi Ahmed
Mar 18, 2005·Annual Review of Immunology·Louise J McHeyzer-Williams, Michael G McHeyzer-Williams
Jun 14, 2005·Nature Medicine·Yvette Edghill-SmithGenoveffa Franchini
May 18, 2006·Emerging Infectious Diseases·Walter GerhardDarya Zharikova
Jun 8, 2006·Journal of the National Cancer Institute·Sabine GröschGerd Geisslinger
Jul 11, 2006·Immunological Reviews·Ian J AmannaShane Crotty
Sep 9, 2006·Molecular Interventions·Ravindra RajakariarDerek W Gilroy
Aug 31, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Matthew P Bernard, Richard P Phipps
Sep 18, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patricia K A Mongini
Oct 9, 2007·Biochemical Pharmacology·Peter PyrkoAxel H Schönthal
Jan 17, 2008·Nature Reviews. Microbiology·Gunilla B Karlsson HedestamRichard T Wyatt
May 1, 2008·Expert Review of Vaccines·Rajesh Kumar, Edith A Burns

❮ Previous
Next ❯

Citations

May 9, 2015·Seminars in Cancer Biology·Abbas K SamadiXujuan Yang
Jun 7, 2014·Frontiers in Cellular and Infection Microbiology·Carmela L Pratt, Charles R Brown
Jun 2, 2016·Human Vaccines & Immunotherapeutics·Ezzeldin SalehEmmanuel B Walter
Apr 2, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Patricia K A MonginiDonna Esposito
Oct 24, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nina KimRichard P Phipps
Oct 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hyunjoo LeePatricia K A Mongini
Oct 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jamie J Bernard, Richard L Gallo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.