PMID: 6410442Jan 1, 1983Paper

Chronic insomnia: effects of tryptophan, flurazepam, secobarbital, and placebo

Psychopharmacology
E HartmannC L Spinweber

Abstract

This study compared the effects of l-tryptophan (1 g), secobarbital (100 mg), flurazepam (30 mg), and placebo on sleep in 96 serious insomniacs. Each treatment was given nightly for 7 nights in a separate-group design. Outcome measures were subjective estimates by subjects of a number of sleep parameters during the week of treatment and for 1 week after, and an overall evaluation made by subjects and investigators at the end of the 2 weeks. During the treatment week, flurazepam produced significant improvement on several sleep measures compared to placebo, while tryptophan and secobarbital did not. Flurazepam and secobarbital produced withdrawal symptoms during the post-treatment week, while tryptophan and placebo did not. Sleep latency was not significantly improved by tryptophan during the treatment week, but continued to improve during the post-treatment week, resulting in a significant difference between tryptophan and baseline in week 2.

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Citations

Jul 20, 1987·Life Sciences·M E Trulson, M J Ulissey
May 18, 1987·Life Sciences·J F LipinskiC M Waternaux
Jan 1, 1991·Life Sciences·S Steinberg
Aug 1, 1990·Acta Physiologica Scandinavica·E Merlo PichL F Agnati
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Sep 19, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Oliviero BruniRaffaele Ferri
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Mar 13, 1998·Cephalalgia : an International Journal of Headache·E MartignoniE Corengia
Oct 23, 2019·Expert Opinion on Pharmacotherapy·Oliviero BruniRaffaele Ferri

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