Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Sudarat NimitvilaiJohn J Woodward

Abstract

Alcoholism is associated with changes in brain reward and control systems, including the prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC) has been suggested to have an important role in the development of alcohol-abuse disorders and studies from this laboratory demonstrate that OFC-mediated behaviors are impaired in alcohol-dependent animals. However, it is not known whether chronic alcohol (ethanol) exposure alters the fundamental properties of OFC neurons. In this study, mice were exposed to repeated cycles of chronic intermittent ethanol (CIE) exposure to induce dependence and whole-cell patch-clamp electrophysiology was used to examine the effects of CIE treatment on lateral OFC (lOFC) neuron excitability, synaptic transmission, and plasticity. Repeated cycles of CIE exposure and withdrawal enhanced current-evoked action potential (AP) spiking and this was accompanied by a reduction in the after-hyperpolarization and a decrease in the functional activity of SK channels. CIE mice also showed an increase in the AMPA/NMDA ratio, and this was associated with an increase in GluA1/GluA2 AMPA receptor expression and a decrease in GluN2B NMDA receptor subunits. Following CIE treatment, lOFC neurons displayed a...Continue Reading

References

Sep 1, 1992·Journal of Neuroscience Methods·A R Kay
Jan 1, 1983·Experimental Brain Research·S J ThorpeS Maddison
Jan 1, 1997·Pflügers Archiv : European journal of physiology·A A VelumianP L Carlen
Apr 9, 1999·Nature Neuroscience·Geoffrey SchoenbaumM Gallagher
May 5, 1999·Nature·L Tremblay, W Schultz
Jan 3, 2001·Nature Neuroscience·J O'DohertyC Andrews
Dec 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H BokuraS Kobayashi
Jan 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James D JentschJane R Taylor
May 17, 2002·Progress in Neurobiology·Pankaj Sah, E S Louise Faber
Dec 4, 2003·Behavioural Brain Research·Kerry McAlonan, Verity J Brown
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudio VillalobosRodrigo Andrade
Apr 14, 2004·The European Journal of Neuroscience·Geoffrey SchoenbaumBarry Setlow
May 7, 2004·Journal of Neurophysiology·Mikel Lopez de Armentia, Pankaj Sah
May 12, 2004·Brain and Cognition·Bryan KolbTerry E Robinson
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Sep 9, 2005·Journal of Neurophysiology·Takashi OkamotoHitoshi Morikawa
Nov 11, 2005·Current Opinion in Neurology·Antoine Bechara, Martial Van Der Linden
Jan 26, 2006·Journal of the International Neuropsychological Society : JINS·Antonio Verdejo-GarcíaElkhonon Goldberg
Feb 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca S HammondRobert W Stackman
May 12, 2006·Electrophoresis·Angela Dittmer, Jürgen Dittmer
Mar 9, 2007·Annals of the New York Academy of Sciences·Matthew R RoeschGeoffrey Schoenbaum
Jan 5, 2008·The Journal of Physiology·Henrik H HansenJens D Mikkelsen
Mar 12, 2008·Neuropsychology·Catherine Brawn FortierRegina E McGlinchey
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory B BissonetteElizabeth M Powell
Sep 11, 2009·International Journal of Environmental Research and Public Health·Catherine Brawn FortierRegina E McGlinchey
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Dec 15, 2010·Cerebral Cortex·Hank P JedemaCharles W Bradberry
Feb 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Igor PonomarevR Dayne Mayfield
Sep 4, 2012·Nature Neuroscience·Andrew HolmesMarguerite C Camp
Jan 15, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kimberly A BadanichJohn J Woodward
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lauren DePoyAndrew Holmes
Mar 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather Trantham-DavidsonL Judson Chandler
Aug 15, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily G Lowery-GiontaThomas L Kash
Sep 7, 2014·Biological Psychiatry·Gregory B BissonetteElizabeth M Powell
Feb 11, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Audrey E PadulaPatrick J Mulholland

Citations

May 14, 2016·Trends in Neurosciences·Patrick J MulhollandPeter W Kalivas
Mar 13, 2016·The Journal of Pain : Official Journal of the American Pain Society·Jing XiangAndrew D Hershey
Aug 16, 2016·Psychopharmacology·Kimberly A BadanichCheryl L Kirstein
Sep 2, 2016·Alcoholism, Clinical and Experimental Research·Amy W Lasek
Jun 10, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Giuseppe CosentinoFilippo Brighina
Feb 1, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sudarat NimitvilaiJohn J Woodward
May 18, 2018·Biological & Pharmaceutical Bulletin·Chikako ShimizuToshitaka Nabeshima
Nov 24, 2018·Addiction Biology·Sudarat NimitvilaiJohn J Woodward
Jan 18, 2018·Nature Communications·Rafael RenteriaChristina M Gremel
Jan 8, 2018·Neurochemical Research·Mickaël Naassila, Olivier Pierrefiche
Sep 24, 2019·Journal of Behavioral Addictions·Deokjong LeeYoung-Chul Jung
Oct 1, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sara PeñascoPedro Grandes
Aug 28, 2020·Alcoholism, Clinical and Experimental Research·Chloe N Shields, Christina M Gremel
Aug 18, 2018·Learning & Memory·David M Lovinger, Karina P Abrahao
Sep 24, 2020·Alcoholism, Clinical and Experimental Research·Mitchell D MorningstarChristopher C Lapish
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
Oct 28, 2020·Brain Sciences·Michael C Salling, Neil L Harrison
Jan 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise E MüllerDenis B Rosemberg
Mar 9, 2021·Brain Plasticity·Yosef Avchalumov, Chitra D Mandyam
Mar 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda EltonCharlotte A Boettiger
Jul 1, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Youna Vandaele, Patricia H Janak

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.