Chronic Intermittent Ethanol Exposure Increases Ethanol Consumption Following Traumatic Stress Exposure in Mice.

Frontiers in Behavioral Neuroscience
Veronica M PiggottA C Conti

Abstract

Individuals with post-traumatic stress disorder (PTSD) often use alcohol to cope with their distress. This aberrant use of alcohol often develops into alcohol use disorder (AUD) leading to high rates of PTSD-AUD co-occurrence. Individuals with comorbid PTSD-AUD have more intense alcohol cravings and increased relapse rates during withdrawal than those with AUD alone. Also, individuals with PTSD or AUD alone often show similar psychological behaviors, such as impulsivity and anhedonia. Extensive clinical studies on the behavioral effects of PTSD-AUD comorbidity, namely alcohol use, have been performed. However, these effects have not been well studied or mechanistically explored in animal models. Therefore, the present study evaluated the effects of traumatic stress comorbid with alcohol exposures on ethanol intake, impulsivity, and anhedonia in mice. Adult male C57Bl/6 mice were first exposed to either mouse single-prolonged stress (mSPS), an animal model that has been validated for characteristics akin to PTSD symptoms, or control conditions. Baseline two-bottle choice ethanol consumption and preference tests were conducted after a 7-day isolation period, as part of the mSPS exposure. Next, mice were exposed to air or chronic ...Continue Reading

References

Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·L A Pohorecky
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Aug 1, 1997·Psychoneuroendocrinology·I LiberzonE A Young
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Howard C Becker, Marcelo F Lopez
Feb 3, 2005·The Journal of Nervous and Mental Disease·John H Casada, John D Roache
Mar 17, 2005·Annals of Medicine·Inge Sillaber, Markus S H Henniger
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Charles W HogeCharles S Milliken
Mar 14, 2008·Alcoholism, Clinical and Experimental Research·Xiaoju YangGary S Wand
Mar 28, 2008·Substance Use & Misuse·G MartinottiL Janiri
Nov 13, 2009·Annals of the New York Academy of Sciences·Rachel Yehuda
Nov 18, 2009·Depression and Anxiety·Shigeto YamamotoIsrael Liberzon
Feb 13, 2010·Addiction Biology·Danielle M DickKenneth Sher
Dec 24, 2010·Nature·Laura BevilacquaDavid Goldman
May 7, 2011·Journal of Substance Abuse Treatment·Michelle L DrapkinEdna B Foa
May 11, 2011·Frontiers in Psychiatry·Daniele Stavros HatzigiakoumisLuigi Janiri
Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Mar 27, 2012·Journal of Neurochemistry·Mariana Angoa-PérezDonald M Kuhn
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Oct 23, 2012·Journal of Dual Diagnosis·Ashlee C CarterErica Eaton Short
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lauren DePoyAndrew Holmes
Mar 22, 2014·Substance Abuse and Rehabilitation·Elizabeth RalevskiIsmene Petrakis
Jun 24, 2014·Brain, Behavior, and Immunity·Molly S CroweSteven G Kinsey
Oct 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah N GarfinkelIsrael Liberzon
Dec 3, 2014·The Psychiatric Clinics of North America·Polaris Gonzalez, Karen G Martinez
May 17, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dayun FengShengxi Wu
Nov 13, 2015·The Journal of Nervous and Mental Disease·Ateka A ContractorJon D Elhai
Dec 17, 2015·The Journal of Nervous and Mental Disease·Cherie ArmourRobert H Pietrzak
Dec 20, 2015·Alcoholism, Clinical and Experimental Research·Ismene L PetrakisElizabeth Ralevski
Jan 12, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Katherine M HolleranDanny G Winder
Jun 1, 2016·Psychological Trauma : Theory, Research, Practice and Policy·Michelle E RoleyJon D Elhai
Sep 13, 2016·Psychological Trauma : Theory, Research, Practice and Policy·Erin C BerenzTimothy P York

❮ Previous
Next ❯

Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronica M PiggottAlana C Conti

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
MS Excel
Statistica

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.