Chronic intermittent ethanol exposure reduces presynaptic dopamine neurotransmission in the mouse nucleus accumbens

Drug and Alcohol Dependence
Anushree N KarkhanisSara R Jones

Abstract

Increasing evidence suggests that chronic ethanol exposure decreases dopamine (DA) neurotransmission in the nucleus accumbens (NAc), contributing to a hypodopaminergic state during withdrawal. However, few studies have investigated adaptations in presynaptic DA terminals after chronic intermittent ethanol (CIE) exposure. In monkeys and rats, chronic ethanol exposure paradigms have been shown to increase DA uptake and D2 autoreceptor sensitivity. The current study examined the effects of ethanol on DA terminals in CIE exposed mice during two time-points after the cessation of CIE exposure. DA release and uptake were measured using fast scan cyclic voltammetry in NAc core slices from C57BL/6J mice, 0h and 72h following three weekly cycles (4 days of 16h ethanol vapor/8h room air/day+3 days withdrawal) of CIE vapor exposure. Current results showed that DA release was reduced, uptake rates were increased, and inhibitory D2-type autoreceptor activity was augmented following CIE exposure in mice. Overall, these CIE-induced adaptations in the accumbal DA system reduce DA signaling and therefore reveal several potential mechanisms contributing to a functional hypodopaminergic state during alcohol withdrawal.

References

Aug 1, 1992·Journal of Neurochemistry·R T KennedyR M Wightman
Jan 1, 1990·Annals of the New York Academy of Sciences·M E Wolf, R H Roth
Aug 1, 1994·Neuroscience Letters·W A Cass, G A Gerhardt
Dec 1, 1995·Alcoholism, Clinical and Experimental Research·W J McBrideT K Li
Feb 24, 2001·Neuroscience Letters·D S RothblatJ S Schneider
Feb 14, 2002·Synapse·Paul E M PhillipsJonathan A Stamford
Feb 27, 2003·Alcoholism, Clinical and Experimental Research·George F Koob
Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Amanda TangRueben A Gonzales
May 21, 2004·Nature Reviews. Neuroscience·Roy A Wise
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Howard C Becker, Marcelo F Lopez
Jul 22, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Agustin ZapataToni S Shippenberg
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Agustin Zapata, Toni S Shippenberg
Mar 25, 2008·Alcohol·Naomi YoneyamaDeborah A Finn
May 17, 2008·Alcoholism, Clinical and Experimental Research·N W GilpinG F Koob
Aug 14, 2009·Alcoholism, Clinical and Experimental Research·William C GriffinHoward C Becker
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Pamela MettenJohn C Crabbe
Oct 16, 2010·The Journal of Pharmacology and Experimental Therapeutics·Zachary M JeanesRichard A Morrisett
Dec 7, 2010·Journal of Neurochemistry·Marianne Benoit-MarandFrancois Gonon
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Jul 12, 2011·Nature Neuroscience·Estefanía P BelloMarcelo Rubinstein
Oct 4, 2011·Neuropharmacology·Karina Possa AbrahaoMaria Lucia Oliveira Souza-Formigoni
Sep 27, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William C GriffinHoward C Becker
May 9, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sean B OstlundNigel T Maidment

❮ Previous
Next ❯

Citations

Jul 3, 2015·Brain Sciences·Joan Y Holgate, Selena E Bartlett
Nov 13, 2015·Alcohol·Heather Trantham-Davidson, L Judson Chandler
Nov 20, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·C E Van SkikeK Nixon
Mar 26, 2016·Frontiers in Behavioral Neuroscience·Jennifer R Ayers-RinglerDoo-Sup Choi
Feb 11, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anushree N KarkhanisSara R Jones
Jun 7, 2015·Behavioural Brain Research·Kaziya M LeeKaren K Szumlinski
May 11, 2016·Alcoholism, Clinical and Experimental Research·Catherine A MarcinkiewczThomas L Kash
May 29, 2016·The International Journal of Neuropsychopharmacology·Jing LiJiang Hong Ye
Jul 19, 2016·Alcohol·Cody A SicilianoSara R Jones
Apr 10, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Giovanni AddoloratoDaniela Di Giuda
Feb 28, 2020·Expert Opinion on Pharmacotherapy·Lauren E HoodM Foster Olive
Apr 2, 2020·International Journal of Molecular Sciences·Bin PengXin Wang
May 2, 2020·Journal of Neurochemistry·Suzanne O NolanErin S Calipari
May 8, 2016·Alcoholism, Clinical and Experimental Research·Tracy R ButlerJeffrey L Weiner
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Priscila Fernandes Carrara-NascimentoRosana Camarini
Dec 22, 2017·Nature Communications·Barbara JuarezMing-Hu Han
Oct 22, 2020·Brain Sciences·Claudia V TurcoAimee J Nelson
Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Armando G SalinasDavid M Lovinger
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Roberto U CofresíThomas M Piasecki
May 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brianna E GeorgeSara R Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.