Chronic intermittent hypobaric hypoxia decreases beta-adrenoceptor activity in right ventricular papillary muscle

American Journal of Physiology. Heart and Circulatory Physiology
Yue GuanYi Zhang

Abstract

Chronic intermittent hypobaric hypoxia (CIHH) has an effective cardiac protection against ischemia-reperfusion injury. However, the underlying mechanisms are not fully known. It has been shown that blockade of beta-adrenergic receptor exerts anti-arrhythmic action and improves cardiac remodeling in ischemic myocardium. Thus we determined the influence of CIHH on beta-adrenergic receptor activity in right ventricular papillary muscle of rats. We found that the action potential duration in right ventricular papillary muscle was significantly longer in CIHH rats than in control rats. Activation of beta-adrenergic receptor with dl-isoproterenol dose-dependently increased action potential duration and the contractility in right ventricular papillary muscle. In CIHH rats, the prolonged effect of dl-isoproterenol on action potential duration and the positive inotropic effect were significantly decreased compared with that in control rats. Furthermore, radioligand-binding experiments revealed that the density and affinity of beta-adrenergic receptor in right ventricular myocardium was significantly lower in CIHH rats. In addition, Western blot analysis revealed that the membrane-bound G protein G(s)alpha expression level in cardiac myo...Continue Reading

References

Oct 1, 1992·Journal of Applied Physiology·R KacimiB Crozatier
Dec 1, 1991·Journal of Applied Physiology·S L MaderE Van Lunteren
Feb 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N F VoelkelP B Molinoff
Dec 1, 1995·The American Journal of Physiology·R KacimiB Crozatier
Sep 8, 1998·Journal of Applied Physiology·K MardonB Mazière
Oct 13, 2000·American Journal of Physiology. Cell Physiology·J M PeiT M Wong
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F León-VelardeJ P Richalet
Jan 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M CatelliE Tibirica
Aug 1, 1960·Annals of Internal Medicine·A HURTADO
Jun 9, 2004·The Japanese Journal of Physiology·Yi ZhangZhaonian Zhou
May 10, 2005·Journal of Applied Physiology·P C BéguinC Ribuot
Nov 18, 2005·Journal of Molecular and Cellular Cardiology·Wei-Zhong ZhuZhao-Nian Zhou
Oct 19, 2006·The Journal of Biological Chemistry·Bo ZhouZhong-Yin Zhang
Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·A M D WatsonC N May
Dec 26, 2006·Journal of Molecular and Cellular Cardiology·Pauline C BéguinChristophe Ribuot
Sep 20, 2008·Cardiovascular Research·Akiko Shiroshita-TakeshitaStanley Nattel

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Citations

Jan 5, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Shelby L SteeleSteve F Perry
May 10, 2013·Canadian Journal of Physiology and Pharmacology·Jing-Jing ZhouYi Zhang
Jun 29, 2016·Diabetes Research and Clinical Practice·Yan-Ming TianYi Zhang
Aug 28, 2019·Clinical and Experimental Pharmacology & Physiology·Zhang-Jing ShiYan Wei
Mar 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hui-Cai GuoYong-Li Wang
Jul 2, 2021·Canadian Journal of Physiology and Pharmacology·Yanming TianZhiyong Hou

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