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Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion

American Journal of Physiology. Cell Physiology

Feb 3, 2007

Hang-Mee YeungMan Lung Fung

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Abstract

This study examined Ca(2+) handling mechanisms involved in cardioprotection induced by chronic intermittent hypoxia (CIH) against ischemia-reperfusion (I/R) injury. Adult male Sprague-Dawley rats were exposed to 10% inspired O(2) continuously for 6 h daily from 3, 7, and 14 days. In iso...read more

Mentioned in this Paper

Ischemia
DRUG Screen Quant Caffeine
Reperfusion Injury
Dioxygen
Ryanodine Receptor 3
Calcium
Adenosine Triphosphatases
Left Ventricular Structure
Muscle Cells
Sodium-Calcium Exchanger
Paper Details
References
  • References43
  • Citations18
12345
  • References43
  • Citations18
12

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Chronic intermittent hypoxia alters Ca2+ handling in rat cardiomyocytes by augmented Na+/Ca2+ exchange and ryanodine receptor activities in ischemia-reperfusion

American Journal of Physiology. Cell Physiology

Feb 3, 2007

Hang-Mee YeungMan Lung Fung

PMID: 17267548

DOI: 10.1152/ajpcell.00458.2006

Abstract

This study examined Ca(2+) handling mechanisms involved in cardioprotection induced by chronic intermittent hypoxia (CIH) against ischemia-reperfusion (I/R) injury. Adult male Sprague-Dawley rats were exposed to 10% inspired O(2) continuously for 6 h daily from 3, 7, and 14 days. In iso...read more

Mentioned in this Paper

Ischemia
DRUG Screen Quant Caffeine
Reperfusion Injury
Dioxygen
Ryanodine Receptor 3
Calcium
Adenosine Triphosphatases
Left Ventricular Structure
Muscle Cells
Sodium-Calcium Exchanger

Feeds With Similar Papers

Ischemia & Reperfusion

Ischemia and reperfusion is a pathological condition characterized by an initial restriction of blood supply to an organ followed by the subsequent restoration of perfusion and concomitant reoxygenation. Restoration of blood flow and reoxygenation is frequently associated with an exacerbation of tissue injury and a profound inflammatory response (called ‘reperfusion injury’). Discover the latest research on ischemia and reperfusion here.

Hypoxia

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Here is the latest research.

Related Papers

Paper Details
References
  • References43
  • Citations18
12345
  • References43
  • Citations18
12

Download from

Publisher
PubMed
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