Chronic Intermittent Low-Level Stimulation of Tragus Reduces Cardiac Autonomic Remodeling and Ventricular Arrhythmia Inducibility in a Post-Infarction Canine Model.

JACC. Clinical Electrophysiology
Lilei YuHong Jiang

Abstract

This study investigated whether chronic low-level tragus stimulation (LL-TS) inhibits cardiac sympathetic remodeling and reduces ventricular arrhythmia inducibility in a post-infarction canine model. Low-level vagal stimulation has been shown to suppress cardiac sympathetic activity, which plays an important role in ventricular arrhythmia after myocardial infarction (MI). Our previous studies reported a noninvasive approach to deliver vagal stimulation by transcutaneous stimulation at the tragus, where the auricular branch of the vagus nerve is located. Twenty-two beagles were randomized to the normal control (n = 6), MI (left anterior descending coronary artery ligation without LL-TS [n = 8]), and TS (MI plus LL-TS [n = 8]) groups. LL-TS was delivered 2 h each day at 80% below the threshold which slowed sinus rate. At 2-month follow-up, LL-TS was found to significantly reduce ventricular arrhythmia inducibility (arrhythmia score: 1.8 ± 0.8 vs. 3.6 ± 0.7, p < 0.01, compared to the MI group), decreased left stellate ganglion (LSG) activity (frequency: 32 ± 15 vs. 112 ± 29 impulses/s; and amplitude: 0.15 ± 0.12 mV vs. 0.38 ± 0.12 mV, compared to MI group), and attenuated cardiac sympathetic remodeling induced by chronic MI. The n...Continue Reading

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Citations

Sep 15, 2017·Journal of the American Heart Association·Lilei YuHong Jiang
Jul 16, 2019·Expert Review of Medical Devices·Yuhong WangHong Jiang
Apr 9, 2018·Current Treatment Options in Cardiovascular Medicine·Lingjin MengOlujimi Ajijola
Mar 28, 2019·Frontiers in Physiology·Yanqiu LaiHong Jiang
Mar 20, 2019·Current Cardiology Reports·Veronica DusiOlujimi A Ajijola
Dec 23, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yu WangPeijing Rong
Jan 2, 2021·Frontiers in Physiology·Mingxian ChenShenghua Zhou
Dec 29, 2020·Neuroscience Bulletin·Yu WangPei-Jing Rong
Jun 3, 2021·Journal of Cardiovascular Development and Disease·Konstantinos C ZekiosTheofilos M Kolettis
May 30, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Neal A Chatterjee, Jagmeet P Singh
Oct 1, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Valerie Y H van WeperenOlujimi A Ajijola

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