Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer.

Frontiers in Immunology
Deborah C RubinMarc S Levin

Abstract

The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of the gastrointestinal tract, from mouth to anus, but most commonly involves the distal part of the small intestine or ileum, and colon. UC results in colonic inflammation that can affect the rectum only, or can progress proximally to involve part of or the entire colon. Clinical symptoms include diarrhea, abdominal pain, gastrointestinal bleeding, and weight loss. A serious long-term complication of chronic inflammation is the development of colorectal cancer. A genetic basis for IBD had long been recognized based on the increased familial risk. However, significant discordance for CD in twins, and a much less robust phenotypic concordance for UC, suggested additional factors play a role in disease pathogenesis, including environmental factors. In the past several years, progress in understanding the molecular basis of IBD has accelerated, beginning with the generation of animal models of colitis and progressing to ...Continue Reading

Citations

Nov 20, 2012·Seminars in Immunopathology·Sergei I Grivennikov
Feb 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingchao ZhuHuanlong Qin
Sep 12, 2013·PloS One·Xiao-feng WangWei-jian Guo
Dec 4, 2012·International Journal of Molecular Sciences·Saba HaqFazlul H Sarkar
Jun 21, 2014·Pharmacological Reports : PR·Michał DudarewiczJadwiga Skrętkowicz
Dec 7, 2013·Cell Biochemistry and Biophysics·Hong-Yu ZhouGuo-Hua Zhou
Dec 3, 2014·Clinics in Laboratory Medicine·Margaret ChoZhiheng Pei
Jan 1, 2012·Longevity & Healthspan·Adriana MartoranaGiuseppina Colonna-Romano
Mar 5, 2016·Gut Microbes·Yava L Jones-Hall, Cindy H Nakatsu
Oct 23, 2014·Journal of Cancer Prevention·Dong Hwan KimNam Deuk Kim
Nov 4, 2015·Frontiers in Oncology·Esther NistalJosé Luis Olcoz
Oct 15, 2013·Journal of Cellular and Molecular Medicine·Angela PoehlmannAlbert Roessner
Jul 2, 2014·Molecular Nutrition & Food Research·Mei-Ling TsaiMin-Hsiung Pan
Nov 20, 2013·International Journal of Clinical Practice·R A Stein
Apr 16, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Anisa ShakerDeborah C Rubin
Aug 10, 2013·Free Radical Research·A MangerichG N Wogan
Mar 22, 2014·Critical Reviews in Microbiology·Caroline A KerrGarry N Hannan
May 30, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·D Tromp, D R H Christie
Jun 16, 2015·Biochimica Et Biophysica Acta·Christina C PierreJuliet M Daniel
May 6, 2016·Frontiers in Oncology·Lukas F MagerPhilippe Krebs
Apr 29, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Li Li, Shawn Somerset
Aug 9, 2016·Letters in Applied Microbiology·A WagnerovaR Gardlik
Nov 13, 2015·Gut Pathogens·Janelle A JiminezRichard R E Uwiera
Apr 26, 2016·PloS One·Xuefeng WangJennie L Williams
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hui Zhang, Xuanfu Xu
Mar 26, 2015·Inflammatory Bowel Diseases·Aurélie ReinhardLina Bezdetnaya
Sep 29, 2017·Journal of Medicinal Food·Hyelin SeoJong-Sang Kim

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