Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system

International Journal of Obesity : Journal of the International Association for the Study of Obesity
K KainederT R Pieber

Abstract

The GLP-1 receptor agonist liraglutide is marketed for obesity treatment where it induces body weight reduction possibly via the hypothalamus, which regulates energy homeostasis. In animal studies, acute liraglutide treatment triggers satiety, weight loss and activates thermogenesis in adipose tissue. However, the precise mechanisms how liraglutide affects in particular chronic weight loss are still under investigation. We aimed to evaluate whether chronic hypothalamic or chronic subcutaneous administration of liraglutide induces sustained weight loss through altered adipose tissue function and to what extent hypothalamic neuronal appetite regulators are involved in the liraglutide-induced weight loss in healthy lean rats on a normal diet. We continuously administered liraglutide either intrahypothalamically (10 μg per day) or subcutaneously (200 μg kg-1 per day) for 28 days to lean Sprague Dawley rats (n=8 each). We assessed changes in body weight, adipose tissue mass, adipocyte size and adipose tissue volume in the abdominal region by using micro-CT. We analyzed genetic expression patterns of browning, thermogenic and adipocyte differentiation regulators in adipose tissues as well as particular neuronal appetite regulators in...Continue Reading

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Citations

Jun 26, 2020·Metabolic Syndrome and Related Disorders·Rona ZhouArthur Swislocki
Jun 8, 2019·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros

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Methods Mentioned

BETA
PCR
Assay

Software Mentioned

Siemens Inveon Acquisition Workplace
Olympus analySIS
GraphPad Prism Mac
ALZET
SPSS Statistics

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