PMID: 9171953Jun 1, 1997Paper

Chronic intrarenal infusion of low-dose angiotensin II in dogs increases arterial pressure without impairment of renal function

Clinical and Experimental Pharmacology & Physiology
K M StevensonWarwick P Anderson

Abstract

1. To determine whether chronic angiotensin II (AngII) infusion into the renal artery, at a dose which increases systemic arterial pressure, reduces glomerular filtration rate (GFR) and renal blood flow, AngII was infused at 0.5 ng/kg per min into the renal artery or intravenously in chronically instrumented dogs for 1 month. 2. Mean arterial pressure (MAP) rose significantly (P < 0.05) during the infusion of AngII into the renal artery (+7 +/- 2 mmHg on days 26-30). There were no significant changes in GFR or renal blood flow. When the same dose of AngII was infused intravenously, MAP did not change significantly (-2 +/- 2 mmHg) and there were no significant changes in GFR or in renal blood flow. 3. We conclude that AngII infused into the renal artery for 1 month, at a dose which was initially subpressor, causes a rise in arterial pressure that is not associated with impairment of renal function.

References

Feb 1, 1976·The Journal of Clinical Investigation·R C BlantzB J Tucker
May 1, 1992·Hypertension·R J JohnsonS M Schwartz
Nov 1, 1985·Hypertension·K M Denton, W P Anderson
Mar 1, 1988·The American Journal of Physiology·R J Bloch, D W Pumplin
Aug 1, 1987·Canadian Journal of Physiology and Pharmacology·W P AndersonD Alcorn
Nov 1, 1984·The Journal of Clinical Investigation·A Bellucci, B M Wilkes
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·W P AndersonP I Korner
Oct 1, 1981·Experimental and Molecular Pathology·M Campbell-Boswell, A L Robertson
Jul 23, 1993·Regulatory Peptides·B BunnemannD Ganten
Jan 1, 1993·Hypertension·P W AndersonW A Hsueh

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Citations

Oct 27, 1997·Journal of Pharmacological and Toxicological Methods·R G EvansW P Anderson
Apr 19, 2006·Hypertension·Hartmut SchachingerKlaus Scheffler

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