Chronic Kidney Disease and Exposure to Nephrotoxic Metals

International Journal of Molecular Sciences
Sarah E Orr, Christy C Bridges

Abstract

Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.

References

Jan 1, 1979·Physiological Reviews·J P Hayslett
Jan 1, 1979·Resuscitation·M J MurphyV Parsons
Jan 1, 1978·Pediatric Research·E E ZieglerS J Fomon
Aug 1, 1978·Toxicology and Applied Pharmacology·E C Foulkes
Jan 1, 1992·Journal of Toxicology. Clinical Toxicology·H V AposhianD Carter
Jan 1, 1992·Toxicology and Applied Pharmacology·T TanakaN Imura
Dec 1, 1992·Toxicology and Applied Pharmacology·C DorianC D Klaassen
Dec 1, 1992·Toxicology Letters·R LauwerysA Cardenas
Sep 1, 1992·Journal of Toxicology and Environmental Health·J B Nielsen
Feb 1, 1992·Pflügers Archiv : European journal of physiology·C A PollockM J Field
Aug 1, 1992·Toxicology and Applied Pharmacology·R K ZalupsP J Kostyniak
Feb 1, 1991·Environmental Health Perspectives·B A Fowler, G DuVal
Jul 1, 1990·British Journal of Industrial Medicine·J StaessenC J Bulpitt
Jun 1, 1991·British Journal of Industrial Medicine·H A RoelsM Oversteyns
Nov 1, 1990·Environmental Health Perspectives·P J Landrigan
Dec 1, 1990·Toxicology Letters·R R BellZ Mallory
Feb 1, 1987·Journal of Neurochemistry·T J Simons, G Pocock
Jan 1, 1989·Toxicology and Applied Pharmacology·J A SwenbergM Charbonneau
Jan 1, 1989·Annual Review of Physiology·L G Fine, J Norman
Jan 1, 1989·Biological Trace Element Research·R K ParasharG Mohan
Jan 1, 1989·Archives of Toxicology·A YasutakeM Inoue
Mar 1, 1989·Toxicology Letters·R A Goyer
Mar 1, 1989·Toxicology Letters·G A Porter
Apr 1, 1989·Toxicology and Applied Pharmacology·E Felley-Bosco, J Diezi
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R K Zalups, G L Diamond
Jan 1, 1988·Journal of Toxicology. Clinical Toxicology·B P Bernard, C E Becker
Jan 1, 1987·Progress in Neurobiology·J C StocletP Schaeffer
Apr 1, 1988·Toxicology and Applied Pharmacology·M T Houser, W O Berndt
Jun 30, 1987·Toxicology and Applied Pharmacology·R K ZalupsG L Diamond
Nov 1, 1987·Toxicology and Applied Pharmacology·E Felley-Bosco, J Diezi
May 1, 1986·Toxicology and Applied Pharmacology·M T Houser, W O Berndt

❮ Previous
Next ❯

Citations

Dec 19, 2018·Human & Experimental Toxicology·A Y Al-BrakatiA E Abdel Moneim
Jun 22, 2019·Environmental Science and Pollution Research International·Wael N HozzeinHind M S Alharbi
Aug 31, 2019·International Journal of Molecular Sciences·Seef Saadi FiyadhAhmed El-Shafie
Apr 11, 2019·Scientific Reports·Rafa S AlmeerAhmed E Abdel Moneim
May 5, 2020·PloS One·Buddhi N T W FernandoNishantha Nanayakkara
May 20, 2020·Anais Da Academia Brasileira De Ciências·Mohamed A DkhilSaleh Al-Quraishy
Jun 3, 2020·Environmental Health Perspectives·Arce Domingo-RellosoMaria Tellez-Plaza
Dec 11, 2019·Medicinal Research Reviews·Xiaoxiao YangBinghe Wang
Dec 19, 2018·Journal of Health & Pollution·Adwalia Fevrier-PaulMitko Voutchkov
Oct 24, 2019·BMC Complementary and Alternative Medicine·Mohammad Nazmul HasanSalima Akter
Jan 31, 2020·Chinese Journal of Integrative Medicine·Xue-Zhong Gong
Jun 20, 2020·Environmental Science and Pollution Research International·Lorena Díaz de León-MartínezRogelio Flores-Ramírez
May 31, 2018·Journal of Toxicology and Environmental Health. Part a·Lucélia Moraes-SilvaMaria Ester Pereira
May 17, 2019·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Evelina ChapmanLudovic Reveiz
Aug 18, 2020·Biological Trace Element Research·Xi SunHaifeng Shi
Nov 8, 2018·Toxics·Brilliance Onyinyechi AnyanwuOrish Ebere Orisakwe
Dec 17, 2019·Environmental Science and Pollution Research International·Rafa S AlmeerAhmed E Abdel Moneim
Aug 18, 2020·Environmental Science and Pollution Research International·Simisola O TeyeLi Wang
Dec 8, 2017·Critical Reviews in Clinical Laboratory Sciences·Prasenjit MitraPraveen Sharma
Jul 7, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Jeonghwan LeeJung Pyo Lee
Oct 18, 2020·Environmental Science and Pollution Research International·Ram B Jain
Jan 5, 2021·Bulletin of Environmental Contamination and Toxicology·Andrea C Salazar-PammoGuido Miranda-Chumacero
Feb 23, 2021·Environmental Science and Pollution Research International·Ram B Jain
Mar 7, 2021·Diagnostics·Hui-Ju TsaiChao-Hung Kuo
Feb 20, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Huda A Al DoghaitherHassan A Alharbi
Jun 12, 2021·Environmental Monitoring and Assessment·Onyenekenwa Cyprian Eneh
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tristen G BridleJürgen Gailer
Jun 10, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Hung-Chen LinPao-Hsien Chu
Aug 9, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yu BaoXiaobo Yang
Aug 17, 2021·Revista Portuguesa De Cardiologia·Hung-Chen LinPao-Hsien Chu
Aug 28, 2021·Children·Yuri Levin-SchwartzAlison P Sanders
Sep 2, 2021·Saudi Journal of Biological Sciences·Mohammad Nasiruddin RanaArwa A Makki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners
Mikki Meadows-Oliver
Kidney International
F S Wright, G Giebisch
© 2022 Meta ULC. All rights reserved