Chronic kidney disease and long-term outcomes of myocardial infarction

International Journal of Cardiology
Michitaka NagashimaHiroshi Ogawa

Abstract

Although chronic kidney disease (CKD) is a risk factor for cardiovascular disease, information about myocardial infarction (MI) with CKD is limited in the acute revascularization era. To clarify the relationship between CKD and long-term outcomes of MI, consecutive 4550 patients with acute MI treated at 17 participating hospitals were analyzed. The primary study outcome was death from any cause, and a secondary endpoint was the first appearance major adverse cardiovascular events. Acute revascularization therapies were performed in 75.2% of the patients and the mean left ventricular ejection fraction (LVEF) was 53%. The median follow-up was 4.1 years (follow-up rate, 95.2%). Patients were divided into four categories (<45.0, 45.0 to 59.9, 60.0 to 74.9, and ≥ 75.0 mL/min per 1.73 m(2) of body-surface area) according to the glomerular filtration rate (GFR) estimated by the Modification of Diet in Renal Disease equation. A total of 1941 (42.7%) patients had an estimated GFR of <60.0 mL/min per 1.73 m(2). Mortality rates increased with declining estimated GFR. Unadjusted hazard ratios for total and cardiovascular death in the group with an estimated GFR of 45.0 to 59.9 mL/min per 1.73 m(2) using the group with an estimated GFR of ≥...Continue Reading

References

Sep 17, 1998·The New England Journal of Medicine·C A HerzogA J Collins
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Oct 29, 2003·Circulation·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Nov 12, 2003·The New England Journal of Medicine·Marc A PfefferUNKNOWN Valsartan in Acute Myocardial Infarction Trial Investigators
Apr 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN Kidney Disease Outcomes Quality Initiative (K/DOQI)
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 2, 2004·Kidney International·Garabed EknoyanHaiyan Wang
Mar 1, 2006·American Heart Journal·François SchieleJean-Pierre Bassand
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Apr 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Liam G GlynnAndrew W Murphy

❮ Previous
Next ❯

Citations

Sep 2, 2020·Journal of Nephrology·Giacomo DeferrariEdoardo La Porta
Jun 29, 2021·IJC Heart & Vasculature·Mark CoyleCatriona Jennings

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.