Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters

Thyroid : Official Journal of the American Thyroid Association
Walter ReinhardtJosef Köhrle

Abstract

Chronic kidney disease (CKD) impairs thyroid hormone (TH) metabolism and is associated with low serum triiodothyronine (T3) concentrations in patients with a low glomerular filtration rate (GFR). Whether this results from decreased T3 formation from thyroxine (T4) by impaired 5'-deiodinase (DIO) activity and/or enhanced degradation of T3 and increased reverse triiodothyronine (rT3) formation from T4 by elevated 5-DIO activity remains unclear. Both activating 5'- and the inactivating 5-deiodination of TH are catalyzed by three selenium (Se)-dependent DIO isoenzymes. Selenoprotein P (SePP) is the major constituent of serum selenium, and functions as Se transport protein from liver to kidney and several other organs. This study tested the hypothesis that serum SePP and TH status are associated with the degree of renal impairment in patients with CKD. A total of 180 CKD patients (stages 1-5) and 70 chronic hemodialysis (CHD) patients undergoing hemodialysis three times per week for at least two years were prospectively investigated for clinical data, parameters of renal function, serum TH profile (thyrotropin, T4, free thyroxine [fT4], T3, free triiodothyronine (fT3), rT3, thyroxine-binding globulin [TBG]), C-reactive protein (CRP)...Continue Reading

References

Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·E M KapteinS G Massry
May 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·J W FooteB Lloyd
Jan 1, 1987·The American Journal of the Medical Sciences·B DworkinL Weiss
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·E M KapteinS G Massry
Sep 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Persson-MoschosB Akesson
Dec 1, 1995·Clinical Science·O OlivieriR Corrocher
Sep 1, 1996·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·P Brätter, V E Negretti de Brätter
Dec 1, 1996·Biological Trace Element Research·G NapolitanoF Monaco
Oct 28, 1999·The American Journal of Clinical Nutrition·A J DuffieldS Williams
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V S Lim
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Sing-Yung WuInder J Chopra
Dec 15, 2005·The British Journal of Nutrition·Christine D ThomsonAnna J Lillico
Jun 16, 2006·Kidney International·C ZoccaliP Pizzini
May 30, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O WitzkeW Reinhardt
Jan 5, 2008·The Journal of Biological Chemistry·Gary E OlsonRaymond F Burk
Feb 9, 2008·The American Journal of Clinical Nutrition·Margaret P RaymanGeoffrey J Beckett
Mar 6, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Birgit HollenbachLutz Schomburg
Dec 20, 2008·European Journal of Endocrinology·P Iglesias, J J Díez
Dec 25, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang Heon SongJin Sup Park
Jan 13, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kostja RenkoLutz Schomburg
May 1, 2009·The American Journal of Clinical Nutrition·Gerald F CombsBlossom H Patterson
Aug 21, 2009·The American Journal of Clinical Nutrition·Christine D ThomsonVicki Livingstone
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Giuseppe Barbesino
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yosuke FujishimaTomoaki Fujioka
Jul 26, 2011·The International Journal of Artificial Organs·Mao-Lin LiuTing-Ying Jiang
Oct 20, 2011·Nature Reviews. Endocrinology·Lutz Schomburg
Aug 21, 2012·The Journal of Clinical Endocrinology and Metabolism·Antonia HoegGraham R Williams
Jan 31, 2015·The Journal of Clinical Endocrinology and Metabolism·Connie M RheeKamyar Kalantar-Zadeh

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Citations

Sep 7, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hong XuJuan Jesús Carrero
Dec 16, 2016·International Journal of Molecular Sciences·Salvatore PettaFerruccio Bonino
Aug 10, 2018·Indian Journal of Endocrinology and Metabolism·Swati SrivastavaRaman Sharma
Dec 5, 2018·Aging Clinical and Experimental Research·Zhonglin CaiHongjun Li

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Methods Mentioned

BETA
SePP
deamination

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