Chronic kidney disease in the pathogenesis of acute ischemic stroke

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Bharath Chelluboina, Raghu Vemuganti

Abstract

Chronic kidney disease has a graded and independent inverse impact on cerebrovascular health. Both thrombotic and hemorrhagic complications are highly prevalent in chronic kidney disease patients. Growing evidence suggests that in chronic kidney disease patients, ischemic strokes are more common than hemorrhagic strokes. Chronic kidney disease is asymptomatic until an advanced stage, but mild to moderate chronic kidney disease incites various pathogenic mechanisms such as inflammation, oxidative stress, neurohormonal imbalance, formation of uremic toxins and vascular calcification which damage the endothelium and blood vessels. Cognitive dysfunction, dementia, transient infarcts, and white matter lesions are widespread in mild to moderate chronic kidney disease patients. Uremic toxins produced after chronic kidney disease can pass through the blood-brain barrier and mediate cognitive dysfunction and neurodegeneration. Furthermore, chronic kidney disease precipitates vascular risk factors that can lead to atherosclerosis, hypertension, atrial fibrillation, and diabetes. Chronic kidney disease also exacerbates stroke pathogenesis, worsens recovery outcomes, and limits the eligibility of stroke patients to receive available stroke...Continue Reading

References

Nov 1, 1995·Journal of Vascular and Interventional Radiology : JVIR·J I Weitz
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M KawamuraT Eto
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·M P WautierJ L Wautier
May 23, 2002·Brain : a Journal of Neurology·Matthew C KiernanHugh Bostock
Jul 12, 2002·British Journal of Pharmacology·Martina Hayer-ZillgenHeinz Bönisch
Oct 2, 2002·Arthritis and Rheumatism·Nathalie Busso, John A Hamilton
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Yusuke SuzukiJesus Egido
Jul 9, 2003·Kidney International·Stephen L SeligerCatherine O Stehman-Breen
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 7, 2004·Current Medical Research and Opinion·Michel E Bertrand
Feb 11, 2005·Clinical and Experimental Hypertension : CHE·Lewis Landsberg, Mark Molitch
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kazunori ToyodaMitsuo Iida
Aug 9, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Neetu TyagiSuresh C Tyagi
Oct 13, 2006·Journal of the American Society of Nephrology : JASN·Christiane Rüster, Gunter Wolf
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Ann M O'HareC Seth Landefeld
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Keattiyoat WattanakitAaron R Folsom
Jan 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmine Zoccali
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Kebin HuYouhua Liu
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George TsagalisKonstantinos N Vemmos
Oct 25, 2008·American Journal of Hypertension·Leonardo A SechiCristiana Catena
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Li-Jun Ma, Agnes B Fogo
Apr 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stephen M SozioRulan S Parekh
May 27, 2009·Cerebrovascular Diseases·Elizabeth MostofskyMurray A Mittleman
May 28, 2009·Journal of the American Society of Nephrology : JASN·Sharon AndersonUNKNOWN workshop participants
Jul 18, 2009·Journal of Neurology·H M den HertogUNKNOWN PAIS investigators
Sep 16, 2009·Seminars in Nephrology·Suma Prakash, Ann M O'Hare
Dec 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Scott D CohenPaul L Kimmel
Apr 28, 2010·Journal of Cardiovascular Pharmacology·Bernard M Y Cheung
May 5, 2010·Annals of Internal Medicine·Andrew D RuleMark D Stegall
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carmen Sánchez-PeralesAntonio Liébana
Jul 16, 2010·The Journal of Clinical Investigation·Tobias V LanzLawrence Steinman
Sep 24, 2010·Kidney International·Manjula Kurella Tamura, Kristine Yaffe
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Mina YuDuk-Hee Kang
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Meng LeeBruce Ovbiagele
Feb 19, 2011·International Journal of Hypertension·Vito M CampeseJeanie Park
May 4, 2011·Journal of Pharmaceutical Sciences·Hiroshi WatanabeToru Maruyama
Aug 17, 2011·Seminars in Immunopathology·Victor W M van Hinsbergh
Sep 23, 2011·Cold Spring Harbor Perspectives in Biology·Wolfgang Bergmeier, Richard O Hynes

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Citations

Nov 27, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ZhaoJieli Chen
Jun 26, 2020·Frontiers in Cardiovascular Medicine·Marius MiglinasArturas Vinikovas
Sep 27, 2020·The European Journal of Neuroscience·Birva ShahPallab Bhattacharya
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Justin D SprickJeanie Park
Oct 18, 2020·International Journal of Clinical Practice·Marwa MohsenRaghda R S Hussein
Apr 21, 2021·Stroke; a Journal of Cerebral Circulation·Zien ZhouUNKNOWN CREDENCE Trial Investigators*
Jul 18, 2021·Frontiers in Neuroendocrinology·Pan CuiJunwei Hao
Aug 24, 2021·Frontiers in Neuroscience·Ya-Ting HuangShu-Long Yang

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