Chronic kidney disease is associated with increased risk of venous thromboembolism recurrence

Thrombosis Research
Marcello RattazziPaolo Pauletto

Abstract

It is currently unclear whether chronic kidney disease (CKD) and the decrease in renal function can influence the risk of venous thromboembolism (VTE) recurrence. We performed an ambispective observational study on 409 patients with a previous episode of VTE. All the patients were included in the retrospective analysis whereas a subgroup of 260 individuals, without history of recurrence and that stopped oral anticoagulation, were then followed-up for a mean of 52.3±20.7months. At the enrollment, subjects with history of recurrent VTE were prevalently male with higher blood pressure and lower eGFR. Prevalence of CKD (defined as eGFR<60ml/min/1.73m2) was higher in patients with previous VTE recurrence with an adjusted OR of 5.69 (IC95% 2.17-14.90, p<0.001) compared to patients with normal eGFR. Similar findings were obtained from the prospective study where an adjusted 5.32 HR for VTE recurrence was seen in patients with CKD compared to subjects with normal renal function (IC95% 1.49-18.95, p=0.010). An increase in the risk of recurrent VTE was also observed in patients with mild decrease in renal function (eGFR 60-90 vs ≥90ml/min/1.73m2 adjusted HR 2.84, IC95% 1.13-7.11, p=0.025). Moreover, a multivariate Cox regression analysis...Continue Reading

Citations

Sep 11, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Yijian ZhangBin Pi
Jun 25, 2020·Toxins·Regiane Stafim da CunhaAndréa Emilia Marques Stinghen
Jul 15, 2020·Internal and Emergency Medicine·Chiara FantoniWalter Ageno
Oct 29, 2020·JAMA Network Open·Shinya GotoUNKNOWN GARFIELD-VTE Investigators
Dec 19, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Stavros K KakkosMelina Vega de Ceniga
Dec 31, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Jeffrey I WeitzPeter Verhamme
Oct 21, 2020·Journal of Thrombosis and Haemostasis : JTH·Lara De LucchiMarcello Rattazzi
Apr 4, 2021·Toxins·Justyna Fryc, Beata Naumnik
Jan 18, 2020·Thrombosis Research·Yoshiaki TsuyukiUNKNOWN COMMAND VTE Registry Investigators
Feb 5, 2019·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Valdis ĢībietisAndris Skride
Jan 25, 2022·Journal of Thrombosis and Thrombolysis·Martin MurgierUNKNOWN RIETE Investigators

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