Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus.

Nutrition & Metabolism
Kaiying GuoYiying Zhang

Abstract

Leucine may function as a signaling molecule to regulate metabolism. We have previously shown that dietary leucine supplementation significantly improves glucose and energy metabolism in diet-induced obese mice, suggesting that leucine supplementation could potentially be a useful adjuvant therapy for obesity and type 2 diabetes. Since the underlying cause for obesity and type 2 diabetes is multifold, we further investigated metabolic effects of leucine supplementation in obese/diabetes mouse models with different etiologies, and explored the underlying molecular mechanisms. Leucine supplementation was carried out in NONcNZO10/LtJ (RCS10) - a polygenic model predisposed to beta cell failure and type 2 diabetes, and in B6.Cg-Ay/J (Ay) - a monogenic model for impaired central melanocortin receptor signaling, obesity, and severe insulin resistance. Mice in the treatment group received the drinking water containing 1.5% leucine for up to 8 months; control mice received the tap water. Body weight, body composition, blood HbA1c levels, and plasma glucose and insulin levels were monitored throughout and/or at the end of the study period. Indirect calorimetry, skeletal muscle gene expression, and adipose tissue inflammation were also a...Continue Reading

References

Sep 1, 1966·The Journal of Clinical Investigation·J C FloydJ Rull
Jul 1, 1995·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·L M BotionR H Migliorini
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S HotamisligilB M Spiegelman
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K R WesterterpV Rolland
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J K KimG I Shulman
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yiying ZhangRudolph L Leibel
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Christopher J LynchThomas C Vary
Nov 22, 2002·The Journal of Biological Chemistry·Changhong LiCharles A Stanley
Jan 24, 2003·Diabetes·Michael W SchwartzRudolph L Leibel
May 23, 2003·The New England Journal of Medicine·Gary D FosterSamuel Klein
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Margriet S Westerterp-Plantenga
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 18, 2003·The Journal of Clinical Investigation·Haiyan XuHong Chen
Aug 7, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·I LabayenJ A Martínez
Nov 3, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T ChristiansenJ M Bruun
Nov 3, 2004·The Journal of Clinical Investigation·Leanne Wilson-FritchSilvia Corvera
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Anne BouloumiéRudi Busse
Dec 13, 2005·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
Dec 21, 2005·The Journal of Nutrition·Donald K Layman, Denise A Walker
May 13, 2006·Science·Daniela CotaRandy J Seeley
Jul 19, 2006·The Journal of Biological Chemistry·Stefan M SchiekeToren Finkel
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Jul 10, 2007·American Journal of Physiology. Endocrinology and Metabolism·You-Ree ChoJason K Kim
Sep 19, 2007·Journal of Internal Medicine·A W Ferrante
Oct 14, 2008·Immunity·Thomas WeichhartMarcus D Säemann
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R L Leibel
Feb 5, 2009·American Journal of Physiology. Endocrinology and Metabolism·Chongben ZhangJie Chen
Feb 27, 2009·The Journal of Nutrition·Ali NairiziChristopher J Lynch
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clémence BlouetGary J Schwartz
Jun 10, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Suzanne Devkota, Donald K Layman

❮ Previous
Next ❯

Citations

Jul 21, 2011·Amino Acids·Fengna LiGuoyao Wu
Aug 11, 2012·The Proceedings of the Nutrition Society·Caroline André, Daniela Cota
Jan 23, 2014·International Journal of Molecular Sciences·Klaus J PetzkeSusanne Klaus
Oct 8, 2014·Nature Reviews. Endocrinology·Christopher J Lynch, Sean H Adams
Dec 22, 2015·Acta Pharmacologica Sinica·Yang ZhaoMing-jiang Xu
Oct 20, 2015·Amino Acids·Nicholas P Gannon, Roger A Vaughan
Feb 23, 2012·British Journal of Pharmacology·Aileen J F King
Dec 22, 2011·Diabetes·Ya SuRoger Gutiérrez-Juárez
Jun 4, 2016·Trends in Pharmacological Sciences·Kang YaoYulong Yin
Jun 22, 2016·Mechanisms of Ageing and Development·Richard A PerryTyrone A Washington
Feb 20, 2016·Nutrients·Isabel Arrieta-CruzRoger Gutiérrez-Juárez
Jan 30, 2018·Molecular Nutrition & Food Research·Nicholas P GannonRoger A Vaughan
Jun 28, 2015·Food & Nutrition Research·Xue-Wei YuanLi-Qiang Qin
Aug 17, 2018·Current Diabetes Reports·Zoltan Arany, Michael Neinast
Apr 18, 2014·The Journal of Endocrinology·Xuefeng YangWenhong Cao
Nov 27, 2019·American Journal of Physiology. Endocrinology and Metabolism·Hexirui WuJamie I Baum
Jun 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yehui DuanXiangfeng Kong
Feb 14, 2013·The Journal of Biological Chemistry·Xuefeng YangWenhong Cao
Jul 4, 2018·International Journal of Molecular Sciences·Kuan-Hsing ChenJan-Kan Chen
May 8, 2015·The American Journal of Clinical Nutrition·Archana P LamichhaneElizabeth J Mayer-Davis
Aug 6, 2019·Journal of Clinical Biochemistry and Nutrition·Motoko TakaokaMasaru Ohtani
May 11, 2019·Current Diabetes Reviews·Anshul ShakyaSurajit Kumar Ghosh
Aug 7, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Oana AncuRichard W Mackenzie
Dec 8, 2020·Molecular and Cellular Endocrinology·Maayan Dadon-FreibergOren Froy

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
light microscopy

Software Mentioned

STATISTICA

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.