Chronic leukocytosis associated with clozapine treatment

Clinical Schizophrenia & Related Psychoses
Michael A Sopko, Charles F Caley

Abstract

Clozapine is an important second-generation antipsychotic that is reserved for patients with refractory schizophrenia. Unfortunately, clozapine is also associated with a number of adverse effects, with agranulocytosis being one of the chief concerns. Interestingly, patients who receive clozapine treatment may occasionally experience elevations in their total white blood cell count (WBC). In some of these patients, the leukocytosis may be persistent. We report the case of a patient with refractory schizophrenia who is treated with clozapine and who experienced chronic leukocytosis. A brief review of the literature addressing clozapine-associated leukocytosis follows the case report.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Aug 1, 1995·Journal of Clinical Psychopharmacology·A Popli, R Pies
Jul 15, 1993·The New England Journal of Medicine·S L Gerson
Mar 29, 2007·The Journal of Clinical Psychiatry·Subramoniam MadhusoodananDinara Amanbekova

❮ Previous
Next ❯

Citations

Sep 13, 2011·Psychosomatics·Fong LiuStephen Ferrando
Mar 19, 2011·Human Psychopharmacology·Patty M M NooijenRobert J Flanagan
Jun 3, 2015·BMJ Case Reports·Vincenzo PriscoMichele Fabrazzo
Dec 7, 2016·Acta Psychiatrica Scandinavica·M I JakobsenA Fink-Jensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Journal of Psychopharmacology
A CaykoyluO Deniz
Movement Disorders : Official Journal of the Movement Disorder Society
Maximilian GahrBirgit Abler
Schizophrenia Bulletin
Ranganath D RattehalliMichael Smith
© 2021 Meta ULC. All rights reserved