PMID: 12787074Jun 6, 2003Paper

Chronic lithium administration potentiates brain arachidonic acid signaling at rest and during cholinergic activation in awake rats

Journal of Neurochemistry
Mireille BasselinStanley I Rapoport

Abstract

Studies were performed to determine if the reported 'proconvulsant' action of lithium in rats given cholinergic drugs is related to receptor-initiated phospholipase A2 signaling via arachidonic acid. Regional brain incorporation coefficients k* of intravenously injected [1-14C]arachidonic acid, which represent this signaling, were measured by quantitative autoradiography in unanesthetized rats at baseline and following administration of subconvulsant doses of the cholinergic muscarinic agonist, arecoline. In rats fed LiCl for 6 weeks to produce a therapeutically relevant brain lithium concentration, the mean baseline values of k* in brain auditory and visual areas were significantly greater than in rats fed control diet. Arecoline at doses of 2 and 5 mg/kg intraperitoneally increased k* in widespread brain areas in rats fed the control diet as well as the LiCl diet. However, the arecoline-induced increments often were significantly greater in the LiCl-fed than in the control diet-fed rats. Lithium's elevation of baseline k* in auditory and visual regions may correspond to its ability in humans to increase auditory and visual evoked responses. Additionally, its augmentation of the k* responses to arecoline may underlie its repor...Continue Reading

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Citations

Feb 19, 2005·Psychopharmacology·Sandra GhelardoniFrancesca Bosetti
Jul 5, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Epolia RamadanStanley I Rapoport
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Dec 20, 2011·Brain Research Bulletin·Mireille BasselinStanley I Rapoport
Jun 27, 2009·Brain Research Reviews·Stanley I RapoportJagadeesh S Rao
Jan 29, 2011·Journal of Neurochemistry·Chris J ReisenauerThad A Rosenberger
May 16, 2006·Biological Psychiatry·Renee N ErtleyJagadeesh S Rao
Apr 30, 2009·The International Journal of Neuropsychopharmacology·Jagadeesh S RaoHyung-Wook Kim
Aug 16, 2016·Seizure : the Journal of the British Epilepsy Association·Lehong GaoYing Liu
Nov 25, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Apr 7, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Feb 11, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Robin E Duncan, Richard P Bazinet
Sep 17, 2009·Biochemical Society Transactions·Richard P Bazinet
Jan 23, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Federico M DarayM Elizabeth Sublette

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