Chronic lithium treatment inhibits pilocarpine-induced mossy fiber sprouting in rat hippocampus

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
David W CadotteL Trevor Young

Abstract

Lithium remains the gold standard in the treatment of bipolar disorder. Long-term treatment with lithium may lead to specific adaptational changes in gene expression that contribute to a neuroprotective effect. In this study, the pilocarpine model of spontaneous limbic epilepsy was used to induce mossy fiber sprouting (axonal growth of the dentate granule cells that synapse on the pyramidal cells of the CA3 region) to examine the prophylactic neuroprotective effects of lithium in vivo. There were four groups of animals: pilocarpine treated (Pil+/Li-); pilocarpine treated followed by lithium (Pil+/Li+); lithium alone (Pil-/Li+); control (Pil-/Li-). Timm staining was used to obtain density measurements in the stratum oriens and the inner molecular layer of the hippocampus. Mossy fiber density was higher in the pilocarpine-treated animals compared to controls. Chronic lithium following pilocarpine treatment attenuated the density of mossy fibers but lithium alone had no effect. No changes in hilar volume or neuronal number were detected using stereological procedures. The ability of lithium to attenuate activation-induced reorganization in the hippocampus provides evidence for its role as a neuroprotective agent in an in vivo mode...Continue Reading

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Citations

Apr 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaan YucelGlenda M MacQueen
Mar 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gwendolyn E WoodBruce S McEwen
Jun 6, 2008·Brain Research·Armando CardosoNikolai V Lukoyanov
Apr 27, 2013·Acta Psychiatrica Scandinavica·J D Gray, B S McEwen
May 18, 2007·The International Journal of Neuropsychopharmacology·Konstantinos N FountoulakisHagop Akiskal
Jan 8, 2015·Journal of Psychiatric Research·C I GiakoumatosM S Keshavan
Feb 10, 2016·Molecular Psychiatry·D P HibarO A Andreassen

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