PMID: 9422313Jan 9, 1998Paper

Chronic liver allograft rejection: a National Institute of Diabetes and Digestive and Kidney Diseases interinstitutional study analyzing the reliability of current criteria and proposal of an expanded definition. National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database

The American Journal of Surgical Pathology
A J DemetrisK Detre

Abstract

A study was conducted to assess the inter and intrarater agreement for the histopathologic features and diagnosis of chronic rejection (CR) and several other important causes of late liver allograft dysfunction. On two occasions, five pathologists, experienced with liver transplantation, reviewed a set of 49 slides representing a range of diagnoses, without knowledge of the clinical history or liver injury test results. The readings were correlated with the original histopathologic diagnosis, liver injury tests, and clinicopathologic follow-up. Assessment of biopsy adequacy (kappa = 0.69) and portal tract counts (kappa = 0.79) showed good to excellent intrarater agreement, whereas interrater agreement for these variables was moderate to good, respectively (kappa = 0.44 and 0.65). Likewise, the intrarater agreement for the diagnosis of CR (kappa = 0.68), hepatitis (kappa = 0.77), and obstructive cholangiopathy (kappa = 0.55) showed good to excellent agreement, whereas the interrater agreement for these same diagnoses ranged from fair to good (kappa = 0.58, 0.46, and 0.25, respectively). In 18 specimens, there was a near unanimous diagnosis of CR across both readings. These biopsies were obtained at a median of 7.1 months (range,...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J ScheuerG M Dusheiko
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N BachF Schaffner
May 1, 1991·Transplantation·S G HubscherJ Neuberger
May 1, 1990·Transplantation·J D PirschF D Belzer
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S OgumaA J Demetris
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LudwigR A Krom
Jun 1, 1987·AJR. American Journal of Roentgenology·R M WhiteT E Starzl
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G I SlapakR Williams
Jan 1, 1997·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Y L WeiJ E Everhart

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Citations

Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerR A Krom
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y NakazawaA D Clouston
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert SutcliffeNigel Heaton
Jul 17, 2004·Transplantation·Aya Miyagawa-HayashinoToshiaki Manabe
Oct 7, 2006·Current Opinion in Gastroenterology·J H Lefkowitch
Jan 14, 2011·American Journal of Clinical Pathology·Andrew M BellizziJulia C Iezzoni
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mylène SebaghMichel Reynès
Oct 5, 2002·Transplantation·Steven R MartinFernando Alvarez
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Desley A H Neil, Stefan G Hubscher
Oct 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anthony Jake Demetris
Jun 27, 2008·Transplantation·George Mells, James Neuberger
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A R CrawfordJ M Crawford
May 1, 2002·Current Opinion in Nephrology and Hypertension·James S Allan, Joren C Madsen
Aug 11, 2020·Der Pathologe·Hideo A BabaJeremias Wohlschläger
Oct 29, 2005·Journal of Pediatric Gastroenterology and Nutrition·R K AzzamP F Whitington
Nov 11, 1999·The American Journal of Surgical Pathology·K BlakolmerA Demetris
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·R F GarciaP McMaster
Mar 20, 2010·Digestive Diseases and Sciences·Timothy M SchmittHugo J R Bonatti
Sep 27, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·George V MazariegosMiguel Reyes-Mugica
Dec 25, 2003·Archives of Pathology & Laboratory Medicine·Dhanpat JainJames M Crawford
Sep 1, 2010·Surgical Pathology Clinics·Aliya N HusainSarangarajan Ranganathan

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