Chronic low back pain: a mini-review on pharmacological management and pathophysiological insights from clinical and pre-clinical data

Inflammopharmacology
Thomas S W ParkMaree T Smith

Abstract

Globally, low back pain (LBP) is one of the most common health problems affecting humans. The lifetime prevalence of non-specific LBP is approximately 84%, with the chronic prevalence at about 23%. Chronic LBP in humans is defined as LBP that persists for more than 12 weeks without a significant pain improvement. Although there are numerous evidence-based guidelines on the management of acute LBP, this is not the case for chronic LBP, which is regarded as particularly difficult to treat. Research aimed at discovering new drug treatments for alleviation of chronic mechanical LBP is lacking due to the paucity of knowledge on the pathobiology of this condition, despite its high morbidity in the affected adult population. For a debilitating condition such as chronic LBP, it is necessary to assess the sustained effects of pharmacotherapy of various agents spanning months to years. Although many rodent models of mechanical LBP have been developed to mimic the human condition, some of the major shortcomings of many of these models are (1) the presence of a concurrent neuropathic component that develops secondary to posterior intervertebral disc puncture, (2) severe model phenotype, and/or (3) use of behavioural endpoints that have yet...Continue Reading

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Citations

Sep 6, 2020·Clinical and Experimental Pharmacology & Physiology·Thomas S W ParkMaree T Smith
Jul 31, 2020·International Journal of Molecular Sciences·Ramona D'AmicoRosanna Di Paola

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

CatWalk
OpenStax

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