Chronic Low Dose Prostaglandin and Neonatal Heart Block

Pediatric Cardiology
Safwat A AlyHoang H Nguyen

Abstract

Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.

References

Aug 20, 1992·The New England Journal of Medicine·N PeledG Koren
Nov 1, 1974·Circulation·R H AndersonJ L Wilkinson
Jan 1, 2011·BMJ Case Reports·Elisabeth De SmitPhilip Bloom
Aug 12, 2015·Pediatric Cardiology·Alper AykanatGüner Karatekin
Jan 28, 2016·The Journal of Perinatal & Neonatal Nursing·Walid Alhussin, M Terese Verklan
Jun 29, 2016·European Journal of Pediatrics·Alban-Elouen BaruteauChristopher J McLeod

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