Chronic lymphocytic leukemia associated with myelodysplastic syndrome with ring sideroblasts

Southern Medical Journal
Khalil M CharafeddineZiad M Salem

Abstract

Diagnosis of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) and chronic lymphocytic leukemia (CLL) in the same patient is extremely rare. We describe a 69-year-old CLL patient who developed MDS with ring sideroblasts 1 year after diagnosis of CLL and without any previous treatment. Diagnosis was based on flow cytometry, bone marrow aspirate morphology, and iron stain. Our findings indicate that the 2 disorders belong to 2 different hematopoietic clones in this patient. In cases of worsening anemia in CLL patients, it is recommended that an iron stain be performed on bone marrow aspirates to exclude a coexistent malignancy such as refractory anemia with ring sideroblasts.

References

Nov 1, 1979·British Journal of Haematology·E LawlorI J Temperley
Sep 1, 1974·British Journal of Haematology·A G PapayannisC Gardikas
Aug 1, 1973·British Journal of Haematology·P D Roberts, P M Forster
Jan 1, 1983·British Journal of Haematology·B R GreenbergP Walling
Jan 1, 1981·Acta Haematologica·A KornbergO Shalev
Oct 1, 1980·American Journal of Clinical Pathology·M T Hull, J A Griep
Aug 1, 1995·Leukemia & Lymphoma·A Bessudo, T J Kipps
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M SorensenB D Cheson
Jun 1, 1997·Clinical and Laboratory Haematology·R J FrewinA G Smith
Jul 1, 1997·Leukemia Research·L S SylvesterJ S Moore
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonB Freidlin
Mar 11, 2004·Mayo Clinic Proceedings·Tait D Shanafelt, Timothy G Call

❮ Previous
Next ❯

Citations

Aug 26, 2017·Annals of Laboratory Medicine·Gina Zini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.