Chronic lymphocytic leukemia cells bind and present the erythrocyte protein band 3: possible role as initiators of autoimmune hemolytic anemia

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jeremías GallettiMirta Giordano

Abstract

The mechanisms underlying the frequent association between chronic lymphocytic leukemia (CLL) and autoimmune hemolytic anemia are currently unclear. The erythrocyte protein band 3 (B3) is one of the most frequently targeted Ags in autoimmune hemolytic anemia. In this study, we show that CLL cells specifically recognize B3 through a still unidentified receptor. B3 interaction with CLL cells involves the recognition of its N-terminal domain and leads to its internalization. Interestingly, when binding of erythrocyte-derived vesicles as found physiologically in blood was assessed, we observed that CLL cells could only interact with inside-out vesicles, being this interaction strongly dependent on the recognition of the N-terminal portion of B3. We then examined T cell responses to B3 using circulating CLL cells as APCs. Resting B3-pulsed CLL cells were unable to induce T cell proliferation. However, when deficient costimulation was overcome by CD40 engagement, B3-pulsed CLL cells were capable of activating CD4(+) T cells in a HLA-DR-dependent fashion. Therefore, our work shows that CLL cells can specifically bind, capture, and present B3 to T cells when in an activated state, an ability that could allow the neoplastic clone to tri...Continue Reading

References

Jan 1, 1989·The Journal of Experimental Medicine·Z M SthoegerN Chiorazzi
Jan 1, 1989·Methods in Enzymology·J R CaseyR A Reithmeier
Aug 1, 1988·American Journal of Hematology·R H SillsC A Glomski
Nov 1, 1984·Transfusion·U J Dumaswala, T J Greenwalt
Jun 1, 1995·The Journal of Experimental Medicine·A Lanzavecchia
Apr 1, 1993·The Journal of Experimental Medicine·E A Ranheim, T J Kipps
Apr 1, 1995·Clinical Immunology and Immunopathology·F DazziF Caligaris-Cappio
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·G R SambranoD Steinberg
Jun 6, 1994·FEBS Letters·D N Wang
Jul 1, 1993·European Journal of Immunology·R N BarkerP M Lydyard
Apr 1, 1993·The Journal of Clinical Investigation·J P LeddyS I Rosenfeld
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Caligaris-Cappio, T J Hamblin
May 2, 2003·The New England Journal of Medicine·Marta CrespoEmili Montserrat
Nov 18, 2003·British Journal of Haematology·Federico Caligaris-Cappio
Oct 14, 2004·Molecular and Biochemical Parasitology·Enrique WinogradIrwin W Sherman
Nov 25, 2004·Hematology·John C ByrdIan W Flinn
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shannon K O'NeillAlison Finnegan
Mar 26, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Yimin Ge, M Tarek Elghetany
May 24, 2005·Molecular and Biochemical Parasitology·Enrique WinogradIrwin W Sherman
Sep 2, 2005·The Journal of Biological Chemistry·Kazuya HiranoMasatoshi Beppu
Apr 18, 2006·Seminars in Oncology·Terry J Hamblin
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paolo MontiEzio Bonifacio

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Citations

Jun 21, 2018·Expert Review of Hematology·Tim R De BackSanne H Tonino
Jan 31, 2020·Frontiers in Oncology·Bruno Fattizzo, Wilma Barcellini
Jul 31, 2012·Cancer Immunology, Immunotherapy : CII·Mercedes BorgeRomina Gamberale
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Lynn R Goldin, Ola Landgren
Jun 11, 2014·American Journal of Hematology·Carlo ViscoFrancesco Rodeghiero
Dec 23, 2015·Clinical and Experimental Immunology·M GuzmánJ G Galletti
Aug 17, 2021·The Cancer Journal·Nil Albiol, Carol Moreno

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