Chronic lymphocytic leukemia: Time to go past genomics?

American Journal of Hematology
Damien Roos-WeilOlivier A Bernard

Abstract

Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of inter-patient and intra-tumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B-cell lymphoproliferative neoplasms. This article is protected by copyright. All rights reserved.

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Citations

Apr 27, 2017·British Journal of Haematology·Hussein GhamlouchOlivier A Bernard
Jul 22, 2017·Leukemia & Lymphoma·Isabel González-Gascón Y MarínUNKNOWN Grupo Español de Leucemia Linfática Crónica (GELLC) and Grupo Cooperativo Español de Citogenética Hematológica (GCECGH)
Mar 28, 2018·Blood Advances·Enguerran MoulyOlivier A Bernard
Nov 15, 2018·Medical Oncology·Luma Dayane de Carvalho Filiú-BragaFelipe Saldanha-Araujo
Jul 13, 2018·Frontiers in Oncology·Emanuela RosatiPaolo Sportoletti
Jun 2, 2018·Investigational New Drugs·Juliana Carvalho Alves-SilvaFelipe Saldanha-Araujo

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