Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015

Journal of the National Comprehensive Cancer Network : JNCCN
A D ZelenetzNational comprehension cancer network

Abstract

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of effective chemoimmunotherapy regimens. The recently approved small molecule kinase inhibitors (ibrutinib and idelalisib) are effective treatment options for CLL in elderly patients with decreased tolerance for aggressive regimens and in patients with poor prognostic features who do not benefit from conventional chemoimmunotherapy regimens. This portion of the NCCN Guidelines for Non-Hodgkin's Lymphomas describes the recent specific to the incorporation of recently approved targeted therapies for the management of patients with newly diagnosed and relapsed or refractory CLL/SLL.

Citations

Oct 16, 2018·British Journal of Cancer·Marco CordaniMassimo Donadelli
Jun 4, 2016·Der Internist·U R Fölsch, G Hasenfuß
Sep 15, 2020·Curēus·Abigail W ChengSaad Shebrain
Feb 2, 2018·Translational Behavioral Medicine·Gabrielle B RocqueMonika M Safford
Feb 25, 2017·Expert Opinion on Pharmacotherapy·Candida VitaleMarta Coscia
Mar 12, 2016·Expert Opinion on Drug Safety·G RedaA Cortelezzi
Apr 1, 2016·British Journal of Cancer·Davide Rossi, Gianluca Gaidano
Dec 22, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Cuneo, R Foà

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