PMID: 3766127Jan 1, 1986Paper

Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain

Acta Neuropathologica
M YamadaH Tsukagoshi

Abstract

An autopsy case of a 52-year-old man suffering from chronic manganese poisoning (CMP) is reported with determination of the manganese distribution in the brain. The patient had been working in a manganese ore crushing plant since 1965. In 1967 he began to complain of difficulties in walking and diminished libido. Later, he developed various neuropsychiatric symptoms including euphoria, emotional incontinence, masked face, monotonous speech, "cock-walk", increased muscle tone, weakness of upper and lower extremities, tremor of the eye lids, and exaggeration of knee jerks. The major neuropathological change was degeneration of the basal ganglia, in which the pallidum was severely affected. The pallidum disclosed a loss and degeneration of nerve cells, which was especially marked in the medial segment, a prominent decrease of myelinated fibers, and moderate astrocytic proliferation. The substantia nigra was intact. Distribution of manganese in the brain of the present case of CMP was determined using flameless atomic absorption spectrometry and compared with control cases and also a case of Parkinson's disease (PD). There was no significant difference between the control cases and the case of PD in average concentration of mangane...Continue Reading

References

Aug 1, 1979·Journal of the Neurological Sciences·N A LarsenK Heydorn
Jul 19, 1985·Science·R Lewin
Jan 1, 1974·Archives of Neurology·D G CookK A Brait
Jul 1, 1963·Journal of Neuropathology and Experimental Neurology·A PENTSCHEWR M KOVATCH

❮ Previous
Next ❯

Citations

Feb 19, 2000·Journal of Neuroscience Research·A TakedaS Okada
Dec 1, 1995·Metabolic Brain Disease·R F ButterworthG P Layrargues
Feb 19, 2009·Journal of Neurology·Joseph Ferrara, Joseph Jankovic
May 3, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Susana Rivera-MancíaSergio Montes
Oct 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N SuarezH Eriksson
Jun 27, 2002·Journal of the Neurological Sciences·Kenjiro OnoMasahito Yamada
Sep 25, 1997·The Science of the Total Environment·J KristiansenE Sabbioni
Jul 29, 1995·Lancet·D KriegerH Lichtnecker
Aug 8, 2002·Neurotoxicology·R H GwiazdaD R Smith
Aug 6, 2003·Neurotoxicology·Sun Yong BaekYangho Kim
Jul 11, 2002·Brain Research. Molecular Brain Research·Mayka Tomás-CamardielAlberto Machado
Jul 11, 2002·Neurochemistry International·Alan S Hazell
Nov 7, 2003·Neurochemistry International·Diem HaMai, Stephen C Bondy
Nov 5, 2003·Brain Research Bulletin·Paolo ZattaAndrew Taylor
Jan 27, 1998·Brain Research Bulletin·A TakedaS Okada
Jul 2, 2008·Parkinsonism & Related Disorders·P Jenner
Jan 6, 2006·International Journal of Toxicology·Celia A DoddBradley G Klein
Jul 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Juan Pablo PrestifilippoValeria Rettori
Nov 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Jursa, Donald R Smith
Oct 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie A MorenoRonald B Tjalkens
Oct 9, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie A MorenoRonald B Tjalkens
Jan 6, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jeffry D SchroeterHarvey J Clewell
Apr 23, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie A MorenoRonald B Tjalkens
Sep 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason R Cannon, J Timothy Greenamyre
Feb 6, 2002·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Malgorzata Siger-Zajdel, Krzysztof Selmaj
Jun 1, 1993·British Journal of Industrial Medicine·K NelsonC Angle
Apr 21, 2010·Environmental Health Perspectives·Tomás R Guilarte
Jul 20, 2007·Environmental Health Perspectives·Danella HafemanHabibul Ahsan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.