Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus

Experimental & Molecular Medicine
Kuem-Ju LeeKyung-Ho Shin

Abstract

New-born cells continue to proliferate and survive to become mature granule cells in adult rat hippocampus. Although this process, known as neurogenesis, is inhibited by acute stress, it is not clear whether chronic stress affects neurogenesis. To determine whether chronic mild stress (CMS) influences neurogenesis in the adult rat hippocampus, male Sprague-Dawley rats were exposed to CMS and administered bromodeoxyuridine (BrdU) before or after CMS to observe the survival/differentiation or proliferation of new-born cells, respectively. In addition, we measured brain-derived neurotrophic factor (BDNF) mRNA in the granule cell layer (GCL) of the hippocampus, because BDNF is known to play an important role in the survival of new-born cells. CMS significantly decreased the survival of new-born cells in the GCL, but did not influence the proliferation or differentiation of new-born cells. CMS did not affect the proliferation and survival of new-born cells in the hilus. In addition, CMS did not change BDNF mRNA levels in the GCL. These results demonstrate that CMS reduces the survival of new-born cells but not of their proliferation, suggesting that repeated mild stress could influence a part of neurogenesis, but not the whole part ...Continue Reading

Citations

Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Barbara VollmayrFritz A Henn
Sep 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicola D HansonCharles B Nemeroff
Mar 12, 2010·Molecular Brain·Saebom LeeSang Ki Park
Jul 21, 2007·Neural Plasticity·Eleni PaizanisLaurence Lanfumey
Aug 9, 2011·Neurochemical Research·Bárbara TagliariAngela T S Wyse
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta KuberaMichael Maes
May 5, 2010·Behavioural Brain Research·Hsiao Hua Wu, Sabrina Wang
May 18, 2010·Trends in Cognitive Sciences·James B AimoneFred H Gage
Apr 13, 2010·Neurobiology of Disease·Chad E BeyerGarth T Whiteside
Nov 17, 2009·Behavioural Brain Research·Maha ElBeltagyPeter M Wigmore
Jun 5, 2007·Frontiers in Neuroendocrinology·Marian JoëlsPaul J Lucassen
Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Dipesh ChaudhuryMing-Hu Han
Mar 19, 2016·Frontiers in Neuroendocrinology·Juan Triviño-ParedesBrian R Christie
Apr 14, 2016·Stem Cells International·Lachlan HarrisJulian Ik-Tsen Heng
Sep 21, 2011·The European Journal of Neuroscience·Jennifer M BarkerJan Martin Wojtowicz
Aug 9, 2006·Biological Psychiatry·Diane C LagaceAmelia J Eisch
Sep 9, 2015·The International Journal of Neuropsychopharmacology·Chien-Chung ChenKuei-Sen Hsu
Apr 29, 2015·Reviews in the Neurosciences·Deepika Suri, Vidita A Vaidya
Jun 16, 2015·Brain, Behavior, and Immunity·Patrick SüßJohannes C M Schlachetzki
Jan 1, 2015·Neurobiology of Stress·Brunno R LevoneOlivia F O'Leary
Sep 23, 2014·Current Opinion in Neurobiology·Bradley R Miller, René Hen
Jul 11, 2012·Neuroscience and Biobehavioral Reviews·Matthew N HillJoanne Weinberg
Dec 28, 2011·Brain, Behavior, and Immunity·María Laura PalumboAna María Genaro
Apr 25, 2012·Psychoneuroendocrinology·Harris Eyre, Bernhard T Baune
Apr 13, 2011·Psychoneuroendocrinology·Steven R WainwrightLiisa A M Galea

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