Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior

Life Sciences
Song LiYiyuan Tang

Abstract

Exposure to chronic stress in rodents and psychosocial stress in humans has been shown to alter cognitive functions and has been linked to the pathophysiology of mood disorders. The purpose of the present study was to investigate effects and possible mechanisms of a chronic mild stress (CMS) procedure on cognitive behaviors in Swiss albino mice using the object recognition test (ORT) and object location test (OLT). Results showed that CMS exposure impaired cognitive performance and produced amnesia of acquired information in both ORT and OLT. Furthermore, the cognitive impairment was coexistent with increased plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), as well as with enhanced plasma levels of corticosterone (CORT), corticotrophin-releasing hormone (CRH) and adrenocorticotrophic hormone (ACTH). In addition, severe neuronal cell damage was found, as bromodeoxyuridine (BrdU) positive cells and the expression of brain derived neurotrophic factor (BDNF) in dentate gyrus (DG) of hippocampus were decreased after 5 weeks CMS procedure. Taken together, these findings indicated that CMS exposure-induced impairment of cognitive behaviors might be attributed to the stres...Continue Reading

References

Aug 9, 1996·Science·R M Sapolsky
May 16, 2001·Archives of General Psychiatry·A ReichenbergT Pollmächer
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·B E Leonard
Oct 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M W Gittos, M Papp
Jul 20, 2002·Progress in Neurobiology·Chen Xu Wang, Ashfaq Shuaib
Oct 29, 2002·Brain, Behavior, and Immunity·H Anisman, Z Merali
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Marieke Wichers, Michael Maes
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert B FelderAlan Kim Johnson
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph FrancisRobert B Felder
Mar 15, 2003·The Journal of International Medical Research·H JozukaO Nishikaze
Jun 10, 2003·Chembiochem : a European Journal of Chemical Biology·Natalya Lozovaya, Andrew D Miller
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Joachim RothThomas Hübschle
May 14, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Spela MiklicMarija Caman-Krzan
Sep 18, 2004·Trends in Neurosciences·Mark P MattsonBronwen Martin
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Roberta De RosaAntonino Cattaneo
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stephanie RidderPeter Gass
Mar 8, 2006·Pharmacology, Biochemistry, and Behavior·Li SongKinzo Matsumoto
Apr 20, 2006·Neurochemistry International·Florence RageLucia Tapia-Arancibia
Jul 21, 2006·Annals of the New York Academy of Sciences·Flavia del PortoRaffaele D'Amelio
Oct 13, 2006·Stress : the International Journal on the Biology of Stress·N Y L OeiB Bermond
Nov 30, 2006·Psychosomatic Medicine·Anna L MarslandStephen B Manuck
Dec 8, 2006·The American Journal of Psychiatry·John G CsernanskyJohn C Morris
Feb 20, 2007·Psychoneuroendocrinology·Bárbara AisaMaria J Ramírez
May 12, 2007·Journal of the American Geriatrics Society·Miranda T SchramRudi G J Westendorp
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rodrigo MedeirosJoão B Calixto

❮ Previous
Next ❯

Citations

Mar 3, 2010·Archives of General Psychiatry·Zhen WangNorbert Schuff
Nov 28, 2009·Neuromolecular Medicine·Sarah M Rothman, Mark P Mattson
Dec 17, 2009·Molecular Psychiatry·V K PariharA K Shetty
Jul 8, 2014·BioMed Research International·Mikhail StepanichevNatalia Gulyaeva
Nov 25, 2011·Cellular and Molecular Neurobiology·J P ter HorstM S Oitzl
Jan 23, 2016·Frontiers in Integrative Neuroscience·Jiah Pearson-LearyEwan C McNay
Oct 12, 2011·Brain, Behavior, and Immunity·Harris Eyre, Bernhard T Baune
Sep 11, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta KuberaMichael Maes
Feb 9, 2010·Behavioural Brain Research·Amber R SalomonsFrauke Ohl
Jan 12, 2010·Behavioural Brain Research·Ashley DenmarkAllan V Kalueff
Aug 23, 2008·Medical Hypotheses·Aleksandar Kibel, Ines Drenjancević-Perić
Jul 24, 2010·British Journal of Pharmacology·M S García-GutiérrezJ Manzanares
Feb 22, 2014·Journal of Experimental & Clinical Cancer Research : CR·Guo-Hua DengYu Jiang
May 20, 2015·Addiction Biology·María S García-GutiérrezJorge Manzanares
Jul 23, 2011·Neuroscience and Biobehavioral Reviews·Paul J KennedyJohn F Cryan
Jul 11, 2012·Neuroscience and Biobehavioral Reviews·Matthew N HillJoanne Weinberg
Apr 25, 2012·Psychoneuroendocrinology·Harris Eyre, Bernhard T Baune
Jul 10, 2013·Neurobiology of Learning and Memory·Shannon J MooreGeoffrey G Murphy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.