Chronic minocycline treatment exerts antidepressant effect, inhibits neuroinflammation, and modulates gut microbiota in mice

Psychopharmacology
Qi YangBin Feng

Abstract

Minocycline is a second-generation, semi-synthetic tetracycline, and has broad spectrum-antibacterial activity. Interestingly, many studies have demonstrated that minocycline is beneficial for depression, which may be due to its effects on neuroinflammation modulation. Recently, gut microbiota imbalance has been found in depression patient and animal models. Based on the fact of minocycline usually acting as an antibiotic and the relationship between depression, gut microbiota, and neuroinflammation, we designed this study to detect the effects of chronic minocycline treatment on antidepression, neuroinflammation, and gut microbiota modulation. Our results showed that minocycline treatment for 4 weeks, not acute treatment, exerted antidepressant effect in mice exposed to unpredictable chronic mild stress (CUMS). Further results suggested that chronic minocycline treatment inhibited neuroinflammation of hippocampus and altered species abundance and metabolites of gut microbiota. Meantime, we found that chronic minocycline treatment ameliorated intestinal barrier disruption and reduced the bacteriological indexes, such as diamine oxidase, C-reaction protein, and endotoxin in peripheral blood of CUMS mice. To sum up, our findings ...Continue Reading

References

Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y DuS M Paul
Nov 11, 2003·Journal of Microbiological Methods·G C BakerD A Cowan
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Jun 2, 2009·Brain, Behavior, and Immunity·Paul ForsytheJohn Bienenstock
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jan-Hendrik HehemannAlisdair B Boraston
Feb 28, 2013·British Journal of Pharmacology·N Garrido-MesaJ Gálvez
Mar 9, 2013·Cell Death & Disease·K KobayashiK Kadomatsu
Sep 17, 2013·EMBO Molecular Medicine·Maureen J OstaffJan Wehkamp
Nov 22, 2014·Current Opinion in Psychiatry·Sarah DashFelice N Jacka
Apr 18, 2015·Brain, Behavior, and Immunity·Haiyin JiangBing Ruan
Oct 8, 2015·Trends in Neurosciences·Raz YirmiyaRonen Reshef
Oct 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shuhong GuoThomas Y Ma
Apr 22, 2016·Nature Communications·Karpagam SrinivasanDavid V Hansen
Jun 19, 2016·Behavioural Brain Research·Alline C CamposAntonio L Teixeira
Jul 8, 2016·Nature·Kenya Honda, Dan R Littman
Mar 5, 2017·Psychoneuroendocrinology·Anders AbildgaardSten Lund
Nov 6, 2017·Journal of Affective Disorders·Joshua D Rosenblat, Roger S McIntyre
Dec 1, 2017·Nature Neuroscience·Caroline MenardScott J Russo
Jun 15, 2018·Cell Host & Microbe·Kassem MakkiFredrik Bäckhed
Feb 26, 2019·Frontiers in Psychiatry·Stephanie G CheungM Elizabeth Sublette

❮ Previous
Next ❯

Citations

Jul 24, 2021·European Journal of Pharmacology·Anusha GovindulaJayesh Mudgal

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
light microscopy
PCR

Software Mentioned

Quantity One
UPARSE
Agilent Chrom Station
mothur
R
Principal Coordinate Analysis ( PCoA )
GraphPad
DA
erah
LDA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug and Therapeutics Bulletin
The Japanese journal of antibiotics
S MizunoT Ueyama
The Japanese journal of antibiotics
Y MiuraH Shibaki
The Japanese journal of antibiotics
K Yamaji
Archives of Otolaryngology
W J Gould, K H Brookler
© 2021 Meta ULC. All rights reserved