Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord

Neuroscience Letters
M SuzukiTsutomu Suzuki

Abstract

It is well known that prolonged exposure to morphine results in tolerance to morphine-induced antinociception. In the present study, we found that mice that were tolerant to morphine-induced antinociception exhibited an increase in immunoreactivity for the neural cell adhesion molecule in the dorsal horn of the spinal cord, which was highly overlapped with immunoreactivity for the increased metabotropic glutamate receptor 5 induced by morphine. These findings support the idea that repeated stimulation of mu-opioid receptors increases the expression of neural cell adhesion molecule and metabotropic glutamate receptor 5. This phenomenon leads to the enhanced excitatory synaptic transmission in the dorsal horn of the spinal cord, and in turn suppresses the morphine-induced antinociception.

References

Jun 22, 2000·The Journal of Comparative Neurology·F J AlvarezP M Somohano
Oct 26, 2002·Science·Morgan Sheng, Myung Jong Kim
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip WashbourneAlaa El-Husseini

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Citations

May 10, 2011·European Journal of Pharmacology·Wakako Fujita-HamabeShogo Tokuyama
Oct 24, 2007·Peptides·Richard J Bodnar
Mar 27, 2012·European Journal of Pharmacology·Kazuo NakamotoShogo Tokuyama
Sep 23, 2008·The Journal of Biological Chemistry·Ovidiu CosteKlaus Scholich

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