Chronic mucocutaneous candidiasis, from bench to bedside

European Journal of Dermatology : EJD
Kilian EyerichClaudia Traidl-Hoffmann

Abstract

Chronic mucocutaneous candidiasis (CMC) defines a heterogeneous group of orphan and inherited syndromes characterised by chronic and recurrent infections of the skin and mucosa with the yeast Candida. Increasing evidence suggests that this inefficient defence against Candida species is reflected by a DC/T cell defect which results in an impaired Th17 and Th1 immune response and, consecutively, a failed immune instruction of tissue cells. Little is known about the incidence and prognosis of CMC. Clinically, the main complications are debilitating hands (Candida granuloma) and oesophageal stricture with potential mal-digestion/-absorption. Furthermore, the chronic infections are likely a risk factor for the development of squamous cell carcinoma. Since resistance to anti-mycotic drugs evolves rapidly, efficient and flexible therapeutic management is essential for CMC patients.

Citations

Oct 3, 2012·Current Opinion in Allergy and Clinical Immunology·Anne PuelJean-Laurent Casanova
May 7, 2011·Journal of Oral Microbiology·David Williams, Michael Lewis
Nov 19, 2014·Seminars in Immunopathology·Luigina RomaniPaolo Puccetti
Apr 2, 2011·Science·Margarita Dominguez-Villar, David A Hafler
Jan 15, 2013·Journal of Clinical Gastroenterology·Nicolas KlugerAnnamari Ranki
Jan 27, 2011·European Journal of Immunology·Teresa ZelanteLuigina Romani
Mar 12, 2011·Nature Reviews. Immunology·Luigina Romani
Apr 30, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Denisse Vázquez-GonzálezAlexandro Bonifaz
May 7, 2014·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefanie Gilles, Claudia Traidl-Hoffmann
Sep 27, 2014·European Journal of Immunology·Luigina RomaniPaolo Puccetti
Oct 1, 2014·European Journal of Immunology·Stefanie Eyerich, Christina E Zielinski
Jun 30, 2015·Allergo Journal International·Kilian Eyerich, Stefanie Eyerich
Mar 5, 2015·The Journal of Dermatology·Carren Sy HauShinichi Watanabe
Oct 21, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·P RerknimitrK Kabashima
Dec 5, 2018·Frontiers in Immunology·Linda HumbertBoualem Sendid
May 29, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Böer-Auer
Jan 31, 2012·The Journal of Allergy and Clinical Immunology·Karin R Engelhardt, Bodo Grimbacher
Jul 22, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Pilar Blanco LoboOlaf Neth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The New England Journal of Medicine
Erik-Oliver GlockerBodo Grimbacher
Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
V Cuneyt KalfaE Richard Stiehm
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
A R Rabson
© 2021 Meta ULC. All rights reserved