PMID: 8959940Nov 1, 1996Paper

Chronic myelogenous leukemia in blast crisis: retrospective analysis of prognostic factors in 90 patients

Annals of Hematology
Martin GriesshammerH Heimpel

Abstract

Ninety patients with Philadelphia chromosome-positive chronic myelogenous leukemia in blast crisis were reviewed to identify significant prognostic associations. At diagnosis of blast crisis the main clinical, laboratory, and cytogenetic data were recorded and evaluated for prognostic significance. At the time of the analysis 89 patients had died, with a median survival of 11 weeks from diagnosis of blast crisis. Patient characteristics demonstrated in the univariate analysis to have significant association with shorter survival were: thrombocythemia, leukocyte count above 20 x 10(9), Karnofsky index < 50%, nonlymphoid blast cell morphology, cytogenetic clonal evolution, the presence of a double Philadelphia chromosome or trisomy 8, and no response to therapy. In 17 of 59 patients (29%) evaluable for response to therapy a complete or partial remission was achieved. These responders had a significantly longer median survival (25 weeks) as compared with nonresponders (9 weeks). Response to therapy was significantly better in lymphoid blast crisis and in patients without clonal evolution. In a multivariate analysis containing all significant variables of the univariate analysis two parameters retained their prognostic significance...Continue Reading

Citations

Aug 22, 2009·Medical Oncology·Janice P DutcherPeter H Wiernik
Apr 28, 2011·International Journal of Hematology·Soranobu NinomiyaHisataka Moriwaki
Feb 13, 2001·British Journal of Haematology·S J Lee
Apr 7, 2007·Journal of Pediatric Hematology/oncology·Fábio Morato de OliveiraLuiz Gonzaga Tone
Oct 9, 2002·European Journal of Haematology·Yuko HiroseSusumu Sugai
Jun 14, 2012·Leukemia & Lymphoma·Sergej KonoplevCarlos E Bueso-Ramos
Jul 14, 2006·Mayo Clinic Proceedings·Alfonso Quintás-Cardama, Jorge E Cortes
Aug 8, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Shelagh M SzaboJorge Cortes
Oct 20, 2001·Best Practice & Research. Clinical Haematology·A ChaseN C Cross
Aug 13, 2004·American Journal of Hematology·P BernardeschiS Guidi
Mar 1, 2012·British Journal of Haematology·Swagata RoyChris Bartholomew
Sep 5, 2006·Archives of Pathology & Laboratory Medicine·George J Netto, Rana Domiati Saad

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