Chronic myeloid leukemia associated with pure red cell aplasia and terminating in promyelocytic transformation

American Journal of Hematology
A MijovićD Tomin

Abstract

After intermittent treatment with busulphan over a 7-year period for chronic myeloid leukemia (CML) in chronic phase, a 39-year-old female developed leukocytosis in association with pure red cell aplasia (PRCA). Bone marrow examination confirmed erythroid aplasia, and culture revealed a total absence of erythroid progenitor cells. The patient then was treated with azathioprine, corticosteroids, cyclophosphamide, plasma exchange, and cyclosporin A, but she remained erythroblastopenic and transfusion dependent for more than a year, at which time a promyelocytic transformation supervened. The authors propose that this sequence of events, hitherto unreported, is a manifestation of the multistep progression of CML.

References

Jul 28, 1978·JAMA : the Journal of the American Medical Association·M Kitahara
Oct 30, 1971·Lancet·M Seabright
Jan 1, 1983·Acta Haematologica·A M Marmont
Jun 1, 1981·British Journal of Haematology·E N DessyprisS B Krantz

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Citations

Oct 15, 1991·Cancer Genetics and Cytogenetics·T LionO A Haas
Dec 16, 2006·Acta Haematologica·Eijiro OkuTakashi Okamura
Apr 13, 2000·Clinical and Laboratory Haematology·H M Hirri, P J Green
Jan 1, 2013·International Journal of Mental Health·Satabdi ChakrabortySmita N Deshpande
Sep 22, 2020·Case Reports in Hematology·Stephanie WolaninStacey S O'Neill

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