PMID: 8614887Apr 1, 1996Paper

Chronic myeloid leukemia manifested during megakaryoblastic crisis

Southern Medical Journal
C D WuP Rintels

Abstract

We describe a 38-year-old man with a chronic myeloproliferative syndrome characterized by elevated white blood cell and platelet counts and increased blasts in the peripheral blood. Bone marrow aspiration was a "dry tap" and the biopsy specimen was hypercellular with numerous blasts, atypical megakaryocytes, and increased reticulin fibrosis. The blasts exhibited cytochemical reactivity for nonspecific esterase and PAS and immunohistochemically were positive for factor VIII, supporting megakaryoblastic lineage. Cytogenetic studies of peripheral blood revealed the t(9;22)(q34;q11). We interpreted these findings to be most consistent with chronic myeloid leukemia (CML) manifested at the time of megakaryoblastic crisis. Although the initial complete blood count showed leukocytosis and thrombocytosis, the patient subsequently had pancytopenia with clinical and pathologic findings consistent with acute myelofibrosis (AMF). Cytosine arabinoside and etoposide chemotherapy induced remission of the acute leukemia. We conclude that CML infrequently presents itself in megakaryoblastic crisis and that such cases may result in the clinicopathologic syndrome of AMF. The success of chemotherapy in this case also suggests that intensive antileu...Continue Reading

Citations

Jan 23, 2009·Journal of Comparative Pathology·S OkabayashY Yasutomi
Apr 18, 2008·Leukemia Research·Sheeja T PullarkatJonathan W Said
Mar 17, 2010·Hematology/oncology and Stem Cell Therapy·Ali Al-ShehriAsim F Belgaumi
Oct 6, 2006·American Journal of Hematology·L CampiottiA Venco
Oct 26, 2018·Pathology Oncology Research : POR·Rashi KhemkaNehar Kanta Jena
Sep 25, 2002·European Journal of Haematology·Luis Arthur Flores PellosoJosé Orlando Bordin
Jun 4, 2008·Archives of Pathology & Laboratory Medicine·Danielle E WestfallStephen Lee

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