PMID: 9168299Apr 1, 1997Paper

Chronic myelomonocytic leukemia: from biology to therapy

Hematology and Cell Therapy
N CambierC Chomienne

Abstract

Chronic myelomonocytic leukemia represents a distinct myelodysplastic syndrome in which an excess of monocytes is observed both in the blood and bone marrow of the patients. Whereas diagnosis is relatively easy, therapeutic design and efficacy is difficult and no treatment has to date provided complete or significant partial response. In vitro data suggest that the growth and differentiation of myelomonocytic progenitors may be altered inasmuch as monocytic or granulo-macrophagic colonies show spontaneous growth. Different entities may be observed: the childhood form, Juvenile Chronic Myelomonocytic Leukemia (JCML) shows in vitro a typical pattern with constitutive growth of only macrophagic colonies and hypersensitivity to GM-CSF; in the adult form at least two patterns may be observed one close to the JCML form and one more heterogeneous with absence of GM-CSF sensitivity and spontaneous growth of both CFU-GM and CFU-M colonies. Chemotherapy reduces all myeloid colonies in vitro whereas retinoic acid has a selective effect on monocytic colonies with a concomitant increase of CFU-G colonies forwarding an explanation for the correction of pancytopenia observed in some patients. Recent analysis of altered molecular pathways in t...Continue Reading

Citations

Aug 28, 2003·Southern Medical Journal·Amy McCollumJoe C Files
Jan 24, 2004·Leukemia & Lymphoma·Tadeusz RobakJacek Bartkowiak
Jan 27, 2007·Blood·Lorna PearnRichard L Darley
Jun 20, 2007·Leukemia & Lymphoma·Giovanni D'Arena, Nicola Cascavilla
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BeranH Kantarjian
Jul 3, 2009·Blood·Mignon L LohCharlotte M Niemeyer
May 1, 2007·Expert Review of Clinical Immunology·Amani MankaiPierre Youinou
Jul 13, 2002·Expert Review of Anticancer Therapy·V A Morrison
Jul 20, 2002·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Aurea M Flores
Jun 12, 2002·Current Treatment Options in Oncology·J H Ward
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Nov 26, 2002·Hematology·Robert J ArceciPeter D Emanuel
Aug 25, 2004·Hematology/oncology Clinics of North America·Federico Caligaris-Cappio, Paolo Ghia

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