Chronic myeloproliferative disorders: improved platelet aggregation following venesection

British Journal of Haematology
B J Boughton

Abstract

Venesection of 10% of whole blood volume or plateletpheresis was performed in nine patients with chronic myeloproliferative disorders and in five normal control subjects. Before venesection, the patients showed impaired platelet aggregation in 33% of tests, most often in response to stimulation with 9 mumol adrenaline. After venesection, the platelet and megathrombocyte counts increased rapidly and excessively in most patients and platelet aggregation improved markedly. In some cases, spontaneous in vitro aggregation was seen at high platelet concentrations. In two patients impaired platelet aggregation with adrenaline was not corrected. The splenic platelet pool is thought to be the probable source of the new platelets.

References

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Citations

Jan 4, 1990·Klinische Wochenschrift·U KabothW Kaboth
Jan 1, 1983·British Journal of Haematology·B J Boughton, K J Dallinger
Oct 1, 1979·Scandinavian Journal of Haematology·F Toolis, L Paton
Sep 1, 1994·European Journal of Haematology·K Le BlancJ Samuelsson
Feb 1, 1990·European Journal of Haematology·J Kutti
Jan 1, 2008·Deutsches Ärzteblatt International·Fabian P Siegel, Petro E Petrides

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