Chronic myocardial infarction is a substrate for bradycardia-induced spontaneous tachyarrhythmias and sudden death in conscious animals

Journal of Cardiovascular Electrophysiology
Cheryl R KillingsworthRaymond E Ideker

Abstract

Patients with bradycardia can have severe tachyarrhythmias but it is unclear whether bradycardia alone can induce arrhythmias or whether an additional substrate is necessary. While several animal models of ventricular tachycardia (VT) exist, no model has been reported to mimic the clinical condition of spontaneous VT and sudden cardiac death (SCD) in the presence of bradycardia and chronic myocardial infarction (MI) in large animals without manipulation of the autonomic nervous system. We tested the hypothesis that MI and bradycardia cause more spontaneous sustained VT than does bradycardia alone. Sheep (42-56 kg) underwent atrioventricular (AV) node catheter ablation alone (n = 5) or AV node ablation and 150 minutes of angioplasty balloon occlusion of the left anterior descending coronary artery (n = 9). An implantable cardioverter defibrillator delivered rescue shocks and demand pacing at 90 beats per minute for the first week and at 40 beats per minute thereafter. Electrograms were continuously radiotelemetered and recorded for 6 weeks. Acute post-MI VT disappeared by day 4. The sudden bradycardia on day 8 triggered numerous premature ventricular contractions (PVCs) and episodes of sustained VT lasting >30 seconds during the...Continue Reading

References

Dec 1, 1989·Journal of the American College of Cardiology·S MilsteinW J Reyes
Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·P GeelenP Brugada
Mar 3, 1998·Journal of Human Hypertension·J A Millar
Nov 24, 1998·Circulation·D P Zipes, H J Wellens
May 11, 1999·Pacing and Clinical Electrophysiology : PACE·S ReekR E Ideker
Apr 14, 2000·Circulation Research·J M CaoP S Chen
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S C VerduynM A Vos
Mar 5, 2004·Journal of the American College of Cardiology·Moshe SwissaLan S Chen
May 11, 2004·Journal of Electrocardiology·Oscar Díaz-CastroManuel Martínez-Selles

❮ Previous
Next ❯

Citations

Aug 17, 2006·Journal of Cardiovascular Electrophysiology·Lan S ChenPeng-Sheng Chen
Sep 26, 2019·Frontiers in Cardiovascular Medicine·Joseph S Piktel, Lance D Wilson
Oct 5, 2016·Journal of Cardiovascular Development and Disease·Paula CamachoJia-Qiang He

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Related Papers

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Ziad F IssaDouglas P Zipes
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
D L JardineM G Nicholls
Heart Rhythm : the Official Journal of the Heart Rhythm Society
Yong-Mei ChaPeng-Sheng Chen
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Dave T KimM C Fishbein
© 2021 Meta ULC. All rights reserved