PMID: 7543453Aug 1, 1995Paper

Chronic nitric oxide synthase inhibition and carotid artery distensibility in renal hypertensive rats

Hypertension
E DelacrétazB Waeber

Abstract

The goal of the present study was to examine the viscoelastic properties of the carotid artery in genetically identical rats exposed to similar levels of blood pressure sustained by different mechanisms. Eight-week old male Wistar rats were examined 2 weeks after renal artery clipping (two-kidney, one clip [2K1C] Goldblatt rats, n = 53) or sham operation (n = 49). One half of the 2K1C and sham rats received the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME, 1.48 mmol/L) in their drinking water for 2 weeks after the surgical procedure. Mean blood pressure increased significantly in the 2K1C-water (182 mm Hg), 2K1C-L-NAME (197 mm Hg), and sham-L-NAME (170 mm Hg) rats compared with the sham-water rats (127 mm Hg). Plasma renin activity was not altered by L-NAME but significantly enhanced after renal artery clipping. A significant and similar increase in the cross-sectional area of the carotid artery was observed in L-NAME and vehicle-treated 2K1C rats. L-NAME per se did not modify cross-sectional area in the sham rats. There was a significant upward shift of the distensibility-pressure curve in the L-NAME- and vehicle-treated 2K1C rats compared with the sham-L-NAME rats. L-NAME treatment did not alter th...Continue Reading

References

May 1, 1979·Clinical Science·B GribbinP Sleight
Aug 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Y TardyJ J Meister
Feb 1, 1991·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·Y TardyM Arditi
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Citations

Sep 21, 2013·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Elizabeth MercureGuy Cloutier
Nov 17, 2001·Clinical and Experimental Hypertension : CHE·E DelacrétazY Allemann
Mar 10, 2009·Autonomic Neuroscience : Basic & Clinical·James P FisherPaul J Fadel
Apr 25, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J A Haefliger, P Meda
Aug 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Helmy M SiragyRobert M Carey
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner

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