Chronic non-A, non-B hepatitis in pregnancy: outcome and possible transmission to the offspring

Scandinavian Journal of Infectious Diseases
R Wejstål, G Norkrans

Abstract

11 women with chronic non-A, non-B hepatitis (NANBH) were studied during 14 pregnancies. All women remained well, without signs of deterioration of liver function. On the contrary, serum transaminase levels were significantly lower in the latter part of the pregnancy compared to before and after. 12 children were born at full term. One child was born preterm and 1 child was stillborn after 36 gestational weeks. During follow-up, 8 of the children had elevated alanine amino transferase (ALT) levels in serum at least at one sampling occasion. Four children had ALT elevation in consecutive blood samples, 2 of whom had a longlasting ALT elevation, probably due to mother-to-infant transmission of NANBH virus(es).

References

Dec 18, 1986·The New England Journal of Medicine·J H HoofnagleE A Jones
Nov 1, 1987·Scandinavian Journal of Gastroenterology·R WejstålG Norkrans
Mar 3, 1970·Acta Medica Scandinavica·O Lundvall, S Iwarsson
Feb 1, 1982·Biology of Reproduction·P K Siiteri, D P Stites

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Citations

Mar 1, 1990·Journal of Medical Virology·R WejstålG Norkrans
Oct 13, 2001·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K IsoM Takayama
Nov 25, 2004·Clinics in Liver Disease·R P González-Peralta
Jul 1, 1995·Scandinavian Journal of Gastroenterology·R Wejstål
Oct 1, 1994·Clinical Microbiology Reviews·J A Cuthbert

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