Chronic non-A, non-B hepatitis: lack of correlation between biochemical and morphological activity, and effects of immunosuppressive therapy on disease progression

Australian and New Zealand Journal of Medicine
M N SchoemanG C Farrell

Abstract

A study was made of 52 patients considered to probably have chronic non-A, non-B hepatitis who were seen during an eight-year period at Westmead Hospital, Sydney. The patients were followed for a median of 28 months to assess the natural history of the disease and, in a small number of patients, the effect of immunosuppressive therapy on disease progression was examined. In 94% of cases, infection appeared to have been acquired by a parenteral route; the remainder were sporadic infections. Fifty-six per cent of the patients had mild constitutional symptoms and the remainder were asymptomatic. Similarly, 54% of patients had no signs of chronic liver disease and none exhibited signs of hepatic decompensation. Liver biopsies were performed in 42 patients; chronic active hepatitis with or without cirrhosis was present in 90%. However, neither the presence of symptoms nor the degree of biochemical abnormality were predictive of disease severity as determined histologically. Among eight patients treated with corticosteroids (with or without azathioprine), six underwent follow-up liver biopsy. Quantitative analysis of inflammatory and fibrotic changes indicated significant (p less than 0.01) progression of histological severity during...Continue Reading

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·M J Koziel, B D Walker
May 1, 1993·Gastroenterologia Japonica·G C FarrellR Lin
May 1, 1993·Gastroenterologia Japonica·J M RobertsW G Cooksley
Mar 6, 2007·Current Gastroenterology Reports·Michael Charlton
Jul 1, 1996·Baillière's Clinical Gastroenterology·G L Davis
Nov 25, 2004·Clinics in Liver Disease·G L Davis
Jun 1, 1991·Australian and New Zealand Journal of Medicine·R LinG C Farrell
Aug 1, 1995·Australian and New Zealand Journal of Medicine·B C SmithP V Desmond
Jan 17, 1994·The American Journal of Medicine·G L Davis
Aug 1, 1994·Journal of Hepatology·R P Gonzalez-PeraltaJ Y Lau
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael Charlton
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S Lok, M A Gerber
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A SheinerC M Miller
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S CoverdaleG C Farrell
Feb 3, 1998·The American Journal of Gastroenterology·S G ShethS Chopra
Jan 1, 1991·Journal of Gastroenterology and Hepatology·G C Farrell
Jul 10, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M Charlton
Jun 26, 2020·Issues in Mental Health Nursing·Charlotta SunnqvistKarin Örmon
Sep 3, 1990·The Medical Journal of Australia·C LiddleG C Farrell
Mar 20, 1998·Annals of Emergency Medicine·T A Morton, G D Kelen

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