Chronic Non-infectious Uveitis in Patients with Juvenile Idiopathic Arthritis

Ocular Immunology and Inflammation
Anton M KolomeyerDavid S Chu

Abstract

To describe clinical findings and analyze treatment evolution of chronic, non-infectious uveitis in patients with juvenile idiopathic arthritis (JIA). A total of 82 patients (147 eyes) with JIA-related uveitis treated for ≥2 months were included (78% females; 79% bilateral uveitis; 74% anterior uveitis). Outcome measures were visual acuity (VA), inflammation control, side-effects, and surgical procedures. Mean ± SD age at diagnosis was 4.9 ± 3.8 years; mean ± SD follow-up time was 8.7 ± 7.8 years. Mean VA did not significantly change throughout the study. Three (2%) eyes resulted in no light perception (NLP) vision. Thirty (37%) patients underwent 69 procedures. In total, 41 (50%) patients achieved inflammation control. TNF-α inhibitors were significantly associated with inflammation control. Seven (8.5%) patients stopped treatment due to side-effects. JIA is a cause of significant ocular morbidity. TNF-α inhibitor use was associated with inflammation control. Prospective, randomized, double blind clinical trials in this regard are warranted.

References

Apr 5, 2005·Ocular Immunology and Inflammation·Pinar C OzdalJean Deschênes
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Jan 13, 2006·Ophthalmology·Ravindran T RajaramanDavid S Chu
Mar 6, 2007·Lancet·Angelo Ravelli, Alberto Martini
Oct 17, 2009·Ocular Immunology and Inflammation·Jayne E CamugliaAnthony J H Hall
Apr 7, 2010·Expert Opinion on Pharmacotherapy·Frank F Lee, Charles Stephen Foster
Jul 27, 2010·Seminars in Arthritis and Rheumatism·Esperanza PatoUNKNOWN Uveitis Working Group from Spanish Society of Rheumatology
Jul 9, 2011·Current Opinion in Rheumatology·C Egla Rabinovich
Nov 15, 2011·Expert Opinion on Investigational Drugs·Luca CantariniRolando Cimaz
Apr 25, 2012·Ophthalmology·Manuel Díaz-LlopisJ Fernando Arevalo
May 15, 2012·Journal of Ophthalmic Inflammation and Infection·Mridula WilliamAnn-Marie Lobo
Jul 4, 2012·Pediatrics in Review·Maria Espinosa, Beth S Gottlieb
Oct 16, 2012·Ophthalmology·Anthony C GregoryUNKNOWN Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group
May 15, 2013·The Journal of Pediatrics·Charalampia PapadopoulouAngelo Ravelli
Jul 3, 2013·The Journal of Rheumatology·Melissa A LermanJohn H Kempen
Jul 24, 2013·Ocular Immunology and Inflammation·Akbar ShakoorNisha R Acharya
Jul 31, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alfredo AdánLaura Pelegrín
Sep 26, 2013·Ocular Immunology and Inflammation·Adriano MagliMaria Alessio
Nov 2, 2013·Seminars in Ophthalmology·Muhammad Usman SaeedArvind Chandna
Dec 18, 2013·Ophthalmology·Pichaporn ArtornsombudhJohn H Kempen
Jan 15, 2014·Ocular Immunology and Inflammation·Joke de BoerJeannette Ossewaarde-van Norel
Feb 4, 2014·Mediators of Inflammation·Carmen García-De-VicuñaJordi Antón

❮ Previous
Next ❯

Citations

Jul 30, 2016·Ocular Immunology and Inflammation·Emmett T CunninghamManfred Zierhut
Jan 23, 2020·World Journal of Pediatrics : WJP·Ross E Petty, Qi Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.