Chronic nonpulsatile blood flow. II. Hemodynamic responses to progressive exercise in calves with chronic nonpulsatile biventricular bypass

The Journal of Thoracic and Cardiovascular Surgery
R TominagaL A Golding

Abstract

We investigated the effects of stepwise treadmill exercise on animal (calf) hemodynamic variables during chronic nonpulsatile biventricular bypass with ventricular fibrillation. Seven days was allowed for recovery from the effects of anesthesia and surgery; each animal's natural heart was then fibrillated. The pump flows were maintained at nominal rates of 90, 100, and 120 ml.kg-1.min-1 for 1 week each, with the order varying from experiment to experiment. A total of 30 incremental exercise tests were performed on five animals. No significant changes in mean aortic pressure were observed during nonpulsatile perfusion at the three nominal flow rates of nonpulsatile flow either before or during exercise. The systemic vascular resistance decreased significantly during exercise (from 705 +/- 22 to 547 +/- 81 dyne.sec.cm-5, p < 0.01, and from 604 +/- 25 to 510 +/- 15 dyne.sec.cm-5, p < 0.05, at nominal flow rates of 100 and 120 ml.kg-1.min-1, respectively). There were also significant (analysis of variance, Scheffe test, p < 0.05) differences in systemic vascular resistance among three nominal flow rates both before and during exercise. These results suggest that the autonomic nerve reflex control of the cardiovascular system in phy...Continue Reading

References

May 1, 1976·Progress in Cardiovascular Diseases·E E SmithR J White
Jul 1, 1976·Progress in Cardiovascular Diseases·P O Astrand
Jan 1, 1989·The Annals of Thoracic Surgery·R M BolmanJ Saffitz
Mar 1, 1966·Archives internationales de physiologie et de biochimie·P VanhoutteI Leusen
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss

❮ Previous
Next ❯

Citations

Jun 14, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Setsuo TakataniTakashi Yamane
Oct 20, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Satoshi Saito, Tomohiro Nishinaka
Mar 2, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Markus ThalmannErnst Wolner
Dec 1, 1996·The Annals of Thoracic Surgery·K TodaH Takano
Feb 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul L DiGiorgiMehmet C Oz
Jun 7, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kazuyoshi FukunagaYasuhiro Fukui
Apr 1, 2004·The Surgical Clinics of North America·Satoshi SaitoStephen Westaby
May 29, 2013·Anesthesiology Clinics·Michelle Capdeville, Nicholas G Smedira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.