Chronic Obesity and Incident Hypertension in Latina Women Are Associated with Accelerated Telomere Length Loss over a 1-Year Period

Metabolic Syndrome and Related Disorders
Janet M WojcickiElissa Epel

Abstract

Shorter telomere length is associated with increased chronic disease risk in adulthood including diabetes mellitus and cardiovascular risk. Few studies have evaluated the relationship between telomere length change and incident disease risk in populations with a high percentage of overweight and obesity. In an urban Latina population recruited in San Francisco (n = 82) with a high prevalence of overweight and obesity (78.4%), we assessed leukocyte telomere length and telomere length change over a 1-year period in relation to obesity, chronicity of obesity, and incident metabolic disease risk 5-6 years later. We also assessed the relationship between telomere length change over a 1-year period and weight loss. There were no significant associations between baseline telomere length and socio-demographics including age and ethnicity, or current weight status. Telomere length change, however, was associated with being obese at baseline and previous years of chronic obesity. A high percentage of women who were obese at baseline were also obese the year before (90%) and 2 years before (85%). Obesity at baseline was an independent predictor for increased telomere length attrition (β = -346.9, -568.4 to -125.4; P < 0.01). Similarly, ch...Continue Reading

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Citations

Oct 31, 2019·The Journal of International Medical Research·Pan LiuLina Ma
May 22, 2020·Breast Cancer Research and Treatment·Trygve LofterødInger Thune
Feb 6, 2020·Journal of Human Hypertension·Thora Wesenberg KjaerJanet M Wojcicki
Aug 27, 2018·Trends in Endocrinology and Metabolism : TEM·Jun RenYingmei Zhang

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Methods Mentioned

BETA
PCR

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