Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort

PloS One
Miguel J DivoEpiChron—BODE Collaborative Group

Abstract

Aging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. We included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Compa...Continue Reading

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Citations

Jul 4, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bartolome R Celli
Sep 26, 2019·The New England Journal of Medicine·Bartolomé R Celli, Jadwiga A Wedzicha
May 2, 2020·The European Respiratory Journal·Miguel J Divo
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Feb 21, 2021·Respiratory Research·E Córdoba-LanúsC Casanova
Mar 11, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Kristijonas PuteikisElena Jurevičienė
Feb 27, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·M J Jaen-MorenoF Sarramea
May 22, 2021·European Journal of Internal Medicine·Alvar AgustiAlberto Papi
May 21, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Ioanna TsiligianniRudi Peché
May 26, 2021·American Journal of Respiratory and Critical Care Medicine·Francesca PolverinoBartolome Celli
Sep 18, 2021·Journal of Biomedical Informatics·James RaffertyRowena Bailey

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Software Mentioned

Gephi Graph
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Clinical Groups® System ACGH System

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