Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia

Biochemical Pharmacology
Lichao YangXin Jin

Abstract

Oleoylethanolamide (OEA) has been shown to have neuroprotective effects after acute cerebral ischemic injury. The aim of this study was to investigate the effects of chronic OEA treatment on ischemia-induced spatial cognitive impairments, electrophysiology behavior and hippocampal neurogenesis. Daily treatments of 30 mg/kg OEA significantly ameliorated spatial cognitive deficits and attenuated the inhibition of long-term potentiation (LTP) in the middle cerebral artery occlusion (MCAO) rat model. Moreover, OEA administration improved cognitive function in a manner associated with enhanced neurogenesis in the hippocampus. Further study demonstrated that treatment with OEA markedly increased the expressions of brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptors α (PPARα). Our data suggest that chronic OEA treatment can exert functional recovery of cognitive impairments and neuroprotective effects against cerebral ischemic insult in rats via triggering of neurogenesis in the hippocampus, which supports the therapeutic use of OEA for cerebral ischemia.

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Citations

Feb 10, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nicola S OreficeGiuseppe Orefice
Mar 26, 2016·Frontiers in Neuroscience·Margarita Pérez-MartínJuan Suárez
May 6, 2016·Neuroscience Bulletin·Fengyun ZhangDongya Zhu
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Dec 14, 2019·Nature Reviews. Neurology·Luigia CristinoVincenzo Di Marzo
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Aug 1, 2020·Antioxidants·Nadia SadanandanCesar V Borlongan
Apr 9, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ester Pérez-MartínEduardo Weruaga

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